The purpose of this paper is to investigate the existence of symmetric positive solutions of the following nonlinear fourth order system of ordinary differential equations −u (4) (t) = f(t, v), −v (4) (t) = g(t, u), t ∈ [0, 1], with the four-point boundary value conditions u(t) = u(1 − t), u (0) − u (1) = u (t 1) + u (t 2), v(t) = v(1 − t), v (0) − v (1) = v (t 1) + v (t 2), 0 < t 1 < t 2 < 1. By applying Krasnoselskii's fixed point theorem and under suitable conditions, we establish the existence of at least one or at least two symmetric positive solutions of the above mentioned fourth order four-point boundary value problem in cone. Some particular examples are provided to support the analytic proof.