Multiple synchronous primary neoplasms of the breast, colon and rectum after surgery for endometrial cancer: A case report

Markakis, Charalampos; Marinis, Athanasios; Dikeakos, Panagiotis; Grivas, Paraskevas; Voultsos, Mavroudis; Liarmakopoulos, Emmanouil; Zervogiannakou, Patritsia; Rizos, Spyros

doi:10.1016/j.ijscr.2013.01.001

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…MPMN was first described by Billroth in 1889 but the diagnostic criteria were not established until 1932 by Warren and Gates [ 1 , 5 ]. The overall incidence of MPMN is known to be up to 17% based on the site of primary malignancy [ 6 ], and the incidence is expected to rise as cancer screening and therapeutics continue to improve leading to longer survival.…”

Section: Discussionmentioning

confidence: 99%

“…While multiple primary malignant neoplasms (MPMNs) were first described in 1889 [ 1 ], their incidence in recent years has increased due to improvements in screening and therapies leading to longer life expectancy in cancer patients. Although cancer survivors are known to have a higher risk for developing cancer, it is unknown if this risk is the same across all ethnicities.…”

Section: Introductionmentioning

confidence: 99%

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Multiple Primary Malignant Neoplasms in African Americans: A Case Series and Literature Review

Sidhom¹,

Jackson²,

Ali³

et al. 2022

Cureus

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Multiple primary malignant neoplasms (MPMNs) or multiple primary malignancies are defined as two or more histologically distinct malignancies present in the same individual. While second or higher-order malignancies account for approximately 18% of all cancers in the United States, it is reasonable to presume that MPMNs are now occurring more frequently than previously reported. Underserved groups such as blacks and Hispanics may represent a high proportion of these underreported cases due to well-established health disparities. Although the role of health disparities has been well established in single primary malignancies, less is known on racial differences in patients with multiple primaries. In comparing MPMNs by race, blacks have lower survival rates compared to white patients. Moreover, despite the lower overall incidence of MPMNs in blacks compared to white patients, when broken down by the specific types of cancers and gender, there are significant racial disparities in the incidence of prostate cancer and possibly other cancers. Further research and case reports are required to explore the risk factors of developing MPMNs in these groups. Our case series explores three African American patients with MPMNs that are rarely described in the literature and outlines the management challenges of treating multiple malignancies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple Primary Malignant Neoplasms in African Americans: A Case Series and Literature Review

Sidhom¹,

Jackson²,

Ali³

et al. 2022

Cureus

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“…Many of the theories about the etiology of MPMN suggest the role of genetic, hormonal, environmental and immunological factors as well as iatrogenic causes [12] . An increased risk in colorectal, urinary bladder, lung and breast cancer has been associated with endometrial cancer [13] . One study has determined a specific genetic mutation in synchronous breast and colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Synchronous male breast and colon cancer presenting with ileus: A case report

Arı¹,

Tatar²,

Buyukasik³

et al. 2016

International Journal of Surgery Case Reports

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HighlightsCancer developing from more than one origin is called multiple primary cancer (MPC) and is a rare situation.We report a male case presenting to the Emergency Clinic with symptoms of ileus who was diagnosed with synchronous colon and breast cancer.Synchronous colorectal cancer is recognized as an important clinical entity, its clinical and pathological properties as well as prognosis are still undetermined.

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“…Since first described by Billroth in 1889 (1) and after reviewed by Warren and Gates in 1932 (2), specific guidelines have been drawn, however multiple neoplasms can translate in multiple drug resistance which drives clinicians to opt for different strategies (3).…”

Section: Introductionmentioning

confidence: 99%

Debulking mastectomy with electrochemotherapy: a case report of no surgery approach to recurrent breast cancer

Esposito¹,

Siani²,

Pace³

et al. 2021

Transl Cancer Res TCR

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Electrochemotherapy has been shown to be safe, effective and non-invasive loco-regional treatment for chest wall breast cancer recurrence. Electrochemotherapy is a palliative treatment offered to patients with cutaneous metastases from breast cancer, which are not eligible for resection and/or systemic therapy is ineffective or contraindicated. Electrochemotherapy combines the administration of bleomycin with electroporation of tumor cell, intraoperatively. Here we present the case of a women affected by multidrug resistant metastatic synchronous solid cancers who refused radical mastectomy after being diagnosed with recurrent ulcerated right breast cancer. We first describe an extended indication to electrochemotherapy to treat breast cancer recurrence after previous breast conserving surgery. Electroporation-induced necrosis through electrochemotherapy replaced surgery and was delivered in 30 minutes at 5,000 Hz frequencies at 730 V by hexagonal needle under general anesthesia. The necrosis of the remaining breast resulted in a voluminous eschar that was easily removed few months after leaving the chest wall free from macroscopic disease turning in a "bladeless mastectomy". This kind of breakthrough application of electrochemotherapy might be considered to avoid palliative mastectomy in very selected patients. New technologies may help clinicians to find agreement between patient' will and the burden of treatment and might contribute in selected cases to give options to patients not keen on having surgery.

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Multiple synchronous primary neoplasms of the breast, colon and rectum after surgery for endometrial cancer: A case report

Abstract: This case report illustrates the need for physicians to be aware of and counsel patients on the risk of subsequent cancers on endometrial cancer survivors.

Cited by 7 publications

References 8 publications

Multiple Primary Malignant Neoplasms in African Americans: A Case Series and Literature Review

Multiple Primary Malignant Neoplasms in African Americans: A Case Series and Literature Review

Synchronous male breast and colon cancer presenting with ileus: A case report

Debulking mastectomy with electrochemotherapy: a case report of no surgery approach to recurrent breast cancer

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