Multiple transfusions for sickle cell disease in the Democratic Republic of Congo: The importance of the hepatitis C virus

Agasa, Salomon Batina; Dupont, Étienne; Kayembe, T.; Molima, P.; R, Malengela; Kabemba, S.; Andrien, M.; Lambermont, Micheline; Cotton, Frédéric; Vertongen, Françoise; Gulbis, Béatrice

doi:10.1016/j.tracli.2010.09.002

Cited by 35 publications

(28 citation statements)

References 20 publications

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“…Similar result was noticed in Africa [19]. In the African population, a lower incidence of alloimmunization was reported if the transfusion is carried out in the country of origin [20,21] compared to transfusion performed in countries where the majority of donors are Caucasians [22]. In sub-Saharan Africa, there is minimal disparity between donor and recipient antigen profiles; this "ethnic matching" [23] explained a lower risk of red cell alloimmunization.…”

Section: Alloimmunizationsupporting

confidence: 59%

Incompatible blood transfusion in children in Burkina Faso

Kafando¹,

Nana²,

Domo³

et al. 2016

Open J Hematol

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Section: Alloimmunizationsupporting

confidence: 59%

Incompatible blood transfusion in children in Burkina Faso

Kafando¹,

Nana²,

Domo³

et al. 2016

Open J Hematol

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“…A recent study conducted among five University Centers, including Howard University, revealed a higher frequency of HIV-1 long-term nonprogressors among HIV-1-infected SCD patients (44%) as compared with HIV-1-infected controls (13.9%) [108]. Another recently published report from Republic of Congo indicated that frequency of HIV among 127 SCD patients was lower than among 3390 blood donors [109,110]. Our recent analysis of national hospital discharge surveys (1997–2009) showed that SCD is associated with lower frequency of HIV-1 diagnosis (odds ratio 0.33) as compared with other diagnosis [111].…”

Section: Low Prevalence Of Hiv-1 Infection In Sickle Cell Diseasementioning

confidence: 99%

Role of Cellular Iron and Oxygen in the Regulation of HIV-1 Infection

2013

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Despite efficient antiretroviral therapy, eradication of HIV-1 infection is challenging and requires novel biological insights and therapeutic strategies. Among other physiological and environmental factors, intracellular iron greatly affects HIV-1 replication. Higher iron stores were shown to be associated with faster progression of HIV-1 infection and to inversely correlate with the survival of HIV-1 infected patients. Iron is required for several steps in the HIV-1 life cycle, including reverse transcription, HIV-1 gene expression and capsid assembly. Here, the authors present a comprehensive review of the molecular mechanisms involved in iron- and oxygen-mediated regulation of HIV-1 replication. We also propose key intracellular pathways that may be involved in regulating HIV-1 replication, via protein kinase complexes, CDK9/cyclin T1 and CDK 2/cyclin E, protein phosphatase-1 and other host factors.

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“…Although acute febrile jaundice strongly suggests infection with hepatitis viruses in medical practice, patients who test negative for yellow fever are never screened for these viruses. Furthermore, viral hepatitis prevalence data in the DRC are either absent (HDV), scarce (HEV) (21), old (HAV) (22), or limited to asymptomatic patients in urban areas (HBV and HCV) (23–25). Little is known about the prevalence and genetic diversity of these viruses in symptomatic patients.…”

Section: Introductionmentioning

confidence: 99%

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

et al. 2017

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The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic of Congo (DRC) test negative for antibodies against yellow fever virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested for hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the DRC. On a total of 498 serum samples collected from suspected cases of yellow fever from January 2003 to January 2012, enzyme-linked immunosorbent assay (ELISA) techniques were used to screen for antibodies against HAV (IgM) and HEV (IgM) and for antigens and antibodies against HBV (HBsAg and anti-hepatitis B core protein [HBc] IgM, respectively), HCV, and HDV. Viral loads and genotypes were determined for HBV and HVD. Viral hepatitis serological markers were diagnosed in 218 (43.7%) patients. The seroprevalences were 16.7% for HAV, 24.6% for HBV, 2.3% for HCV, and 10.4% for HEV, and 26.1% of HBV-positive patients were also infected with HDV. Median viral loads were 4.19 × 105 IU/ml for HBV (range, 769 to 9.82 × 109 IU/ml) and 1.4 × 106 IU/ml for HDV (range, 3.1 × 102 to 2.9 × 108 IU/ml). Genotypes A, E, and D of HBV and genotype 1 of HDV were detected. These high hepatitis prevalence rates highlight the necessity to include screening for hepatitis viruses in the yellow fever surveillance program in the DRC.

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Multiple transfusions for sickle cell disease in the Democratic Republic of Congo: The importance of the hepatitis C virus

Cited by 35 publications

References 20 publications

Incompatible blood transfusion in children in Burkina Faso

Incompatible blood transfusion in children in Burkina Faso

Role of Cellular Iron and Oxygen in the Regulation of HIV-1 Infection

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

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