Multiple Unit Pellet System (Mups) Based Fast Disintegrating Delayed-Release Tablets for Pantoprazole Delivery

Abstract

Objective: The rationale for the study was to develop multiple unit pellet system (MUPS) of delayed release pantoprazole with desired physical properties and unaltered drug release profile from pellets even after compression into a fast disintegrating tablet. Methods:In the presented study, delayed release pellets of pantoprazole were developed by two methods, i.e. extrusion-spheronization and drug layering techniques, coated using enteric polymer and subsequently compressed in to tablet. In drug layering technique, pantoprazole was loaded on Celphere ® 102 (microcrystalline cellulose spheres) as well as on Suglet ® (sugar spheres) in fluid bed processor. Acid resistant polymer Eudragit ND 30D was subsequently coated on each type of drug loaded pellets. Suitable tableting excipients were prepared such as soft pellets, Ceolus ® (fibrous grade of microcrystalline cellulose) granules, Ludipress ® (compressible lactose composition), Avicel ® PH 200 and different combination of them. Various factors like property of pellets to be compressed, coating level, the composition of tableting excipient and ratio of drug-loaded pellets to tableting excipients were identified and optimized.Results: MUPS with delayed releasing pellets of pantoprazole proved to provide sufficient hardness, rapid disintegration property, and unaltered release profile after compression. Delayed release pantoprazole pellets prepared by drug layering on celphere ® 102 followed by coating with Eudragit ® NE 30D showed better compressibility to withstand the drug release properties. The combination of Ceolus ® granules and Ludipress (in 1:1 ratio) was found to be suitable tableting excipient that helped compression of pellets without rupturing polymeric coat. Pellets to excipients ratio at 1:3 was found optimum. Conclusion:Compaction behaviour of pantoprazole delayed-release pellets without loss of original delayed release profile was achieved by formulating as MUPS based tablet of pantoprazole delayed release pellets using celephere ® 102 was developed which was found suitable for desired release profile and physical properties.

Preparation and Evaluation of Glaucocalyxin A SustainedRelease Pellets Based on Phospholipid Complex System with Enhanced Bioavailability

“…Finally, the pellets were coated through fluidized bed coating technology as described by PateL SA et al with some modifications [31]. The coating polymer suspension was prepared by adding16 g triethyl citrate (as plasticizer) and 530 g Kollicoat SR 30 D to 430 g purified water with stirring for 40 min.…”

Formulation and Investigation of Polymeric Multiple Unit Pellet Systems Consisting of Sustained Release Glimepiride and Immediate Release Atorvastatin Calcium

“…Then, the wet granulation mixture was extruded, and the extrudates were then immediately spheronized to yield the spherical pellets. The pellets were dried in a hot-air oven at 40°C for 10-12 h. The dried pellets were then filled and stored in screw-capped, high-density polyethylene bottles [7].…”

Formulation of Immediate Release (Ir) Atorvastatin Calcium Pellets and Sustained Release (Sr) Glibenclamide for Fixed-Dose Combination Dosage Form

“…Then, the wet granulation mixture was extruded, and the extrudates were then immediately spheronized to yield the spherical pellets. The pellets were dried in hot air oven at 40°C for 10-12 h. After drying, pellets were then filled and stored in screw-capped, high-density polyethylene bottles [9].…”