Multiple valvular regurgitation associated with bromocriptine therapy

Cautres, Thomas; Cautres, Michel; Mohty, Dania

doi:10.1016/j.acvd.2012.06.007

Cited by 3 publications

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“…This association was investigated in only three studies, all cross-sectional, with discrepant findings, most likely due to variation in treatment dose and duration, and lack of statistical power. However, several case reports have suggested an association between bromocriptine and valvular heart disease in PD patients [32,33]. As bromocriptine could potentially act as a partial agonist at the 5-HT2B receptors on heart valves [34], further research is needed.…”

Section: Discussionmentioning

confidence: 99%

Risks of Cardiac Valve Regurgitation and Heart Failure Associated with Ergot- and Non-Ergot-Derived Dopamine Agonist Use in Patients with Parkinson’s Disease: A Systematic Review of Observational Studies

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Risks of Cardiac Valve Regurgitation and Heart Failure Associated with Ergot- and Non-Ergot-Derived Dopamine Agonist Use in Patients with Parkinson’s Disease: A Systematic Review of Observational Studies

et al. 2015

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“…Sobre este tema, los sentimientos de los franceses coinciden con los de los demás europeos respecto a la UE: entre los indicadores de confianza con respecto a las instituciones, las encuestas del Eurobarómetro muestran que los referentes a las instituciones comunitarias son los que más han caído en los últimos diez años en la mayoría de los países de la UE 85 . Aunque esta última desarrolla en ese mismo período importantes esfuerzos de información dirigidos al gran público, sus iniciativas se advierten en primer lugar dependientes de una lógica de comunicación y no de una pedagogía, o de una educación cívica y política 86 .…”

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El reto europeo en las últimas elecciones presidenciales francesas: la confirmación de una nueva línea de fractura

Vayssière

2020

Hist. Polít. Ideas, Procesos Mov. Soc.

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Como demuestran los resultados de la última elección presidencial en Francia de 2017, el malestar europeo se refleja cada vez más en el espejo de la campaña electoral, y con ello el de los franceses: la desconfianza hacia el futuro en la UE expresada por parte de la sociedad francesa ha sido de manera generalizada uno de los componentes de las votaciones de este principio de siglo, ampliando la línea divisoria entre proeuropeos y antieuropeos y dibujando un futuro donde Francia y Europa deben repensar sus vínculos.

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Bromocriptine

2014

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S Bromocriptine Mitral regurgitation, aortic valve regurgitation, and tricuspid regurgitation: case reportA 76-year-old man developed mitral regurgitation, aortic valve regurgitation, and tricuspid regurgitation during treatment with bromocriptine.The man, who had Parkinson's disease treated with bromocriptine 30 mg/day for more than 7 years (total cumulative dose = 77 g) [route not stated], presented with severe dyspnoea, leading to urgent hospitalization for congestive heart failure. His trans-thoracic doppler echocardiography showed a dilated left ventricle with normal ejection fraction without wall motion abnormalities. Both the mitral and the aortic valves were thickened with a drumstick appearance and restrictive motion of the two mitral leaflets causing severe mitral regurgitation. Significant aortic valve regurgitation due to restrictive motion of the right and the noncoronary aortic cusps was noted. Significant tricuspid regurgitation with thickened tricuspid leaflets and a dilated tricuspid annulus was seen and the left atrium was dilated. Coronary angiography revealed three-vessel disease.The man's bromocriptine treatment was interrupted and he was managed medically and still alive. [outcomes not stated]Author comment: "Although there was no histological proof however, given the time course, cumulative dose, chemical similarity of bromocriptine to other ergo derivatives and typical valve lesions seen on [Trans-thoracic Doppler echocardiography], we felt that there was a strong and probable association between prolonged bromocriptine treatment and the occurrence of severe multiple valves disease."Cautres T, et al. Multiple valvular regurgitation associated with bromocriptine therapy.

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Multiple valvular regurgitation associated with bromocriptine therapy

Cited by 3 publications

References 0 publications

Risks of Cardiac Valve Regurgitation and Heart Failure Associated with Ergot- and Non-Ergot-Derived Dopamine Agonist Use in Patients with Parkinson’s Disease: A Systematic Review of Observational Studies

Risks of Cardiac Valve Regurgitation and Heart Failure Associated with Ergot- and Non-Ergot-Derived Dopamine Agonist Use in Patients with Parkinson’s Disease: A Systematic Review of Observational Studies

El reto europeo en las últimas elecciones presidenciales francesas: la confirmación de una nueva línea de fractura

Bromocriptine

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