Multiple Variables Affecting Blood Usage in Lung Transplantation

Wang, Yongping; Kurichi, Jibby E.; Blumenthal, Nancy P.; Ahya, Vivek N.; Christie, Jason D.; Pochettino, Alberto; Kaiser, Larry R.; Sonnad, Seema S.; Pollak, Eleanor S.

doi:10.1016/j.healun.2005.12.004

Cited by 34 publications

(35 citation statements)

References 19 publications

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“…Wang and colleagues confirmed the results of Triulzi (23) and demonstrated less requirement of PRBC, FFP, and platelets during lung transplantation in single-lung transplantation (5). Furthermore, they discovered that the patient's diagnosis had an impact on the amount of blood products required.…”

Section: Predictors Of Blood Loss During Lung Transplantationmentioning

confidence: 65%

Established and potential predictors of blood loss during lung transplant surgery

et al. 2018

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Lung transplantation is an established therapeutic procedure for end stage lung diseases. Its success may be impaired by perioperative complications. Intraoperative blood loss and the resulting blood transfusion are among the most common complications. The various factors contributing to increased blood loss during lung transplantation are only scarcely investigated and not yet completely understood. This is in sharp contrast to other surgical fields, as in orthopedic surgery, liver transplantation and cardiac surgery the contributors to blood loss are well identified. This narrative review article aims to highlight the acknowledged factors influencing blood loss in lung transplantation (such as double vs. single lung transplant) and to discuss potential factors that may be of interest for further research or helpful to develop strategies targeting risk factors in order to minimize blood loss during lung transplantation and finally improve patient outcome.

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Section: Predictors Of Blood Loss During Lung Transplantationmentioning

confidence: 65%

Established and potential predictors of blood loss during lung transplant surgery

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Several issues may affect early outcomes, including the recipient's underlying disease, duration of cardiopulmonary bypass (if used) (29)(30)(31), size discrepancies at the site of anastomosis, and technique for initiating reperfusion. Complications that may be encountered during transplantation include inadequate intrathoracic exposure, intraoperative hypotension, poor hemostasis, compromised anastomosis, inadequate graft function, dynamic pulmonary hypertension, or metabolic and/or respiratory acidosis (32,33).…”

Section: Operative and Perioperative Considerations In Lung Transplanmentioning

confidence: 99%

“…Cardiopulmonary bypass may be used during lung transplantation on an elective basis, such as for very small body size or preexisting pulmonary hypertension; or it may need to be used on an emergent basis for refractory hypercapnia, dynamic pulmonary hypertension, technical complications, inadequate graft function, or poor exposure (30). Although data from the cardiac surgical literature does suggest an inflammatory effect from cardiopulmonary bypass, there is no evidence to suggest that bypass should be delayed when it is clearly indicated during transplantation (30,(34)(35)(36)(37)(38)(39).…”

Section: Operative and Perioperative Considerations In Lung Transplanmentioning

confidence: 99%

“…Although data from the cardiac surgical literature does suggest an inflammatory effect from cardiopulmonary bypass, there is no evidence to suggest that bypass should be delayed when it is clearly indicated during transplantation (30,(34)(35)(36)(37)(38)(39).…”

Section: Operative and Perioperative Considerations In Lung Transplanmentioning

confidence: 99%

“…This is a matter of considerable therapeutic and prophylactic variability among transplant centers. A variety of factors predispose to development of serious bacterial or fungal infections after transplant (55,56), including PGD, cytomegalovirus infection (57, 58), multiple transfusions (30,32), colonization with multiresistant organisms before transplant (59-62), enhanced or extensive immune suppression, renal failure, or episodes of acute rejection. Unfortunately, as therapeutic options for viral infection have improved, fungal organisms predominate, with an incidence of 15 to 35% (56,63).…”

Section: Operative and Perioperative Considerations In Lung Transplanmentioning

confidence: 99%

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