BackgroundAn epileptic appendix torsion is a rare event that can lead to acute abdominal pain and occurs at any age. Chiropractic is a type of complementary medicine that is performed explicitly by spinal manipulations. Specialists use spinal manipulation to treat many musculoskeletal disorders, usually mechanical back and neck pain, headaches, and spinal stiffness. Case presentationA 49-year-old man with a history of progressive diffuse abdominal pain predominately in the left lower quadrant started three days ago was referred to Ghaem Hospital, Mashhad, Iran. All laboratory tests were normal, and no abnormal findings were observed on ultrasound and X-rays, but the CT scan revealed a definite diagnosis of appendicular torsion. Gastrointestinal rest, antibiotics, analgesics, and fluid therapy were started for the patient. After 72 hours, the patient's general condition improved, and he was discharged from the hospital. In this report, we presented a case who developed acute abdominal pain after spinal manipulation. Chiropractic is not a completely safe treatment and can cause irreversible damage, so we should know this method's dangers and have enough experience to provide the best and safest medical services for patients.