Multiple viral coinfections among HIV/AIDS patients in China

He, Na; Chen, Li; Lin, Hung-Ching; Zhang, Man; Wei, Jun; Yang, Jing; Gabrio, Jenna; Rui, Baoling; Zhang, Zuo‐Feng; Fu, Zheng-Wen; Ding, Yingying; Li, Xiaopan; Jiang, Qingwu; Detels, Roger

doi:10.5582/bst.2011.v5.1.1

Cited by 28 publications

(29 citation statements)

References 33 publications

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“…He et al, 36 also did not find any associations with demographic factors, EBV antibodies and HIV infection despite the fact that some malignant EBV-associated diseases are linked to racial characteristics. 37 However, other studies have not found such associations.…”

Section: Resultsmentioning

confidence: 90%

Epstein-Barr virus in oral mucosa from human immunodeficiency virus positive patients

Santos

Azevedo

Silva

et al. 2014

Rev. Assoc. Med. Bras.

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Objective: the detection rate of Epstein-Barr virus (EBV) is higher in people living with human immunodeficiency virus (HIV). In an attempt to contribute to our epidemiological understanding of this coinfection and to investigate the activity of EBV in normal oral mucosa, we performed a cross-sectional study with HIV-positive patients. Methods: oral smears from 145 HIV-positive patients were collected between March 2010 and March 2011. Nested polymerase chain reaction (PCR) and reverse transcriptase-PCR (RT-PCR) were used to genotype EBV and to detect EBNA-2 expression, respectively. Results: EBV DNA was detected in 48.3% of the study participants, of whom 32.85% were EBV-1 and 45.71% were EBV-2 carriers. Additionally, 14.28% were coinfected with both types. EBNA-2 mRNA was expressed in 45.7% of the EBV--positive samples, including 20.0% with EBV-1 only, 20.0% with EBV-2 only and 1.4% with both genotypes. Immune status affected the overall EBV infection, and EBV-2 positivity was significantly correlated with sexual lifestyle of the participants. EBV co-infection with both viral types was dependent upon HIV viral load and the activity of the EBNA-2 gene. Conclusion: we report a high prevalence of active EBV in the oral mucosa of asymptomatic HIV-seropositive individuals. This study addresses the need for monitoring and treatment of HIV-infected patients with EBV reactivation.

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Section: Resultsmentioning

confidence: 90%

Epstein-Barr virus in oral mucosa from human immunodeficiency virus positive patients

Santos

Azevedo

Silva

et al. 2014

Rev. Assoc. Med. Bras.

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“…Nineteen studies reported the prevalence of HCV infection in high-risk populations: ten were from China [17][18][19][20][21][22][23][24][25][26], two from Japan [27,28], two from Korea [29,30] and five from Taiwan [12,[31][32][33][34]. Among high-risk populations, the prevalence of HCV infection was higher among IDUs (48-95 % in China, Table 4).…”

Section: Prevalence Of Hcv Infection In High-risk Populationsmentioning

confidence: 96%

A review of the burden of hepatitis C virus infection in China, Japan, South Korea and Taiwan

Bennett¹,

Waser²,

Johnston³

et al. 2015

Hepatol Int

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Hepatitis C virus (HCV) infection is associated with substantial clinical and economic burden and is an important public health issue in Asia. The objective of this review was to characterize HCV epidemiology and related complications in China, Japan, South Korea and Taiwan. A search of electronic databases and conference abstracts identified 71 potentially relevant articles. Of those, 55 were included in the epidemiology review and 9 in the review of HCV-related complications. HCV prevalence in the general population was 1.6% in China, 0.6-0.9% in Japan, 0.6-1.1% in South Korea and 1.8-5.5% in Taiwan. Prevalence was higher for injecting drug users (48-90%) and those with human immunodeficiency virus coinfection (32-85%) and was lower for blood donors (<1%). Annual incidence of HCV in China was 6.01 per 100,000. HCV genotype 1b was associated with the highest incidence of hepatocellular carcinoma (HCC). Five-year survival for patients with liver cirrhosis was 73.8%, decreasing to 39.2% following liver transplantation; the majority of deaths were attributable to HCC. Limitations were that the majority of studies included in the epidemiology review were small, regional studies conducted in specific populations, and there was an absence of large population-based studies. Thus, estimates may not be representative of the epidemiology of HCV for each country. The prevalence HCV in China and HCV incidence in the Asian region remain largely unknown, and they are likely underestimated. Further epidemiologic and clinical data are needed to provide more precise estimates for use by public health agencies.

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“…In China, common risk factors for liver disease such as alcohol use, HBV and HCV infections are more prevalent in HIV-infected patients than those without HIV infection (9)(10)(11)(12). All-cause mortality was also higher in HIV-infected patients with HBV and/or HCV coinfection(s) than in those with HIV only, although ART has generally increased life expectancy of HIV-infected patients (13).…”

Section: Introductionmentioning

confidence: 99%

Liver fibrosis after antiretroviral therapy in a longitudinal cohort of sexually infected HIV patients in eastern China

Qian

Lin

Ding

et al. 2017

BST

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Multiple viral coinfections among HIV/AIDS patients in China

Cited by 28 publications

References 33 publications

Epstein-Barr virus in oral mucosa from human immunodeficiency virus positive patients

Epstein-Barr virus in oral mucosa from human immunodeficiency virus positive patients

A review of the burden of hepatitis C virus infection in China, Japan, South Korea and Taiwan

Liver fibrosis after antiretroviral therapy in a longitudinal cohort of sexually infected HIV patients in eastern China

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