Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication

Wang, Yilin; Straßl, Robert; Helanterä, Ilkka; Aberle, Stephan W.; Bond, Gregor; Hedman, Klaus; Weseslindtner, Lukas

doi:10.1016/j.jcv.2019.08.012

Cited by 13 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They conducted a longitudinal genoprevalence analysis of 13 HPyVs using serum and urine samples from 99 kidney transplant recipients, grouped by quantitative BKPyV DNA loads and BKPyV associated nephropathy. TSPyV DNA was found in one blood sample total (1.1% of the patients) from a post‐transplant patient who did not display BKPyV DNAemia at the same time, confirming low detection frequency of TSPyV and a limited correlation between TSPyV and BKpyV coinfection as previously described 37 …”

Section: Epidemiologysupporting

confidence: 85%

Recent developments in trichodysplasia spinulosa disease

Narayanan

Rády

Tyring

2020

Transplant Infectious Dis

View full text Add to dashboard Cite

Trichodysplasia Spinulosa (TS) is a rare proliferative skin disease that occurs primarily in immunocompromised patients, specifically organ transplant recipients. TS is characterized by uncontrolled inner root sheath cell proliferation and folliculocentric papular eruption that can progress to disfiguring leonine facies when left untreated. TS presents with distinct histological features including the presence of large eosinophilic, trichohyaline granules within hyperproliferating inner root sheath cells of the hair bulb. The discovery of the Trichodysplasia Spinulosa Polyomavirus (TSPyV) and recent studies highlighting the role of TSPyV tumor antigens in cell proliferation pathways have provided new insight into the mechanisms of TS development. In this review, we discuss the expansion of our understanding of TS, specifically over the past 5 years. We summarize novel cases of TS and recent developments in the mechanisms underlying TSPyV-mediated disease progression. We also evaluate advancements in diagnostic methods and treatment options. As the incidence of TS continues to rise, it is becoming critical for clinicians to understand the clinical features of TS and emerging research regarding pathogenesis and therapeutics for early treatment of this potentially disfiguring disease.

show abstract

Section: Epidemiologysupporting

confidence: 85%

Recent developments in trichodysplasia spinulosa disease

Narayanan

Rády

Tyring

2020

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…The incidence of viremia among kidney transplant recipients varies widely among studies, according to several factors, i.e., time after transplantation, immunosuppressive regimens, and type of sample (blood or urine) initially screened. The incidence in adults initially screened in plasma ranged from 9.2% to 84% up to 1 year after transplantation (97,100,109,110,112,(117)(118)(119)(120)(121). In a recent study of 99 kidney transplant recipients from Finland, BKPyV DNA was detected at least in one plasma sample of 84% of patients by use of a multiplex PCR assay for the detection of 13 human polyomaviruses, with a median viral load of 3.6E4 copies/ml (range, 1E2 to 1.5E9 copies/ml) (121).…”

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

View full text Add to dashboard Cite

SUMMARY Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral signatures or genomes can be identified in the blood of these patients. The identification of novel viral species and variants by metagenomic next-generation sequencing has opened up a new field of investigation and new paradigms. Thus, there is a need to thoroughly describe the state of knowledge in this field with a review of all viral infections that should be scrutinized in high-risk populations. Here, we review the eukaryotic DNA and RNA viruses identified in blood, plasma, or serum samples of pediatric and adult SOT/HSCT recipients and the prevalence of their detection, with a particular focus on recently identified viruses and those for which their potential association with disease remains to be investigated, such as members of the Polyomaviridae, Anelloviridae, Flaviviridae, and Astroviridae families. Current knowledge of the clinical significance of these viral infections with associated viremia among transplant recipients is also discussed. To ensure a comprehensive description in these two populations, individuals described as healthy (mostly blood donors) are considered for comparative purposes. The list of viruses that should be on the clinicians’ radar is certainly incomplete and will expand, but the challenge is to identify those of possible clinical significance.

show abstract

“…Also, HIV-positive men more frequently have detectable MCPyV DNA on their skin and in their sera, and those with poorly-controlled HIV infection have higher MCPyV antibody titers and DNA loads than those with better-controlled infections (Wieland et al, 2011 ; Fukumoto et al, 2013 ; Vahabpour et al, 2017 ). In kidney transplant recipients, MCPyV DNA was more readily detected in the urine of those with BKPyV-DNAemia and with histologically verified polyomavirus-associated nephropathy (Signorini et al, 2014 ; Wang et al, 2019 ). MCPyV DNA detection rates and loads were significantly lower in patients with psoriasis compared to the skin of healthy volunteers suggesting a potential inverse relationship between chronic inflammation in the skin and MCPyV proliferation (Hashida et al, 2019 ).…”

Section: Immune Responses To Mcpyvmentioning

confidence: 99%

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Krump

You

2021

Front. Microbiol.

View full text Add to dashboard Cite

Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to MCPyV-associated MCC. Clearer understanding of host responses that normally control MCPyV infection could inform prophylactic measures in at-risk groups. Similarly, the presence of MCPyV in most MCCs could imbue them with vulnerabilities that-if better characterized-could yield targeted intervention solutions for metastatic MCC cases. In this review, we discuss recent developments in elucidating the interplay between host cells and MCPyV within the context of viral infection and MCC oncogenesis. We also propose a model in which insufficient restriction of MCPyV infection in aging and chronically UV-damaged skin causes unbridled viral replication that licenses MCC tumorigenesis.

show abstract

Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication

Cited by 13 publications

References 25 publications

Recent developments in trichodysplasia spinulosa disease

Recent developments in trichodysplasia spinulosa disease

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Contact Info

Product

Resources

About