Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon

Lee, Youn Jung; Moon, Seung‐Hyeon; Park, Min Geun; Jung, Woon Yong; Park, Yong Keun; Song, Sung Kyu; Ryu, Je Gyu; Lee, Yong Seung; Heo, Hye Jung; Gu, Ha Na; Cho, Su Jeong; Ali, Bahy A.; Al-Khedhairy, Abdulaziz A.; Lee, Ilkyun; Kim, Soonhag

doi:10.1016/j.biomaterials.2016.05.052

Cited by 37 publications

(27 citation statements)

References 52 publications

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“…In this study, we showed that downregulation of piR-004800 decreases the expression of p-AKT and p-mTOR. Influencing the expression of certain tumor-related proteins through silencing mRNA similar to other non-coding small RNAs, piRNA can regulate the origination and development of tumor cells (6,27). The exact mechanism of how piR-004800 regulates PI3K/AKT/mTOR deserves further investigation.…”

Section: Discussionmentioning

confidence: 99%

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival

Wang

Tian

et al. 2020

Front. Oncol.

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Section: Discussionmentioning

confidence: 99%

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival

Wang

Tian

et al. 2020

Front. Oncol.

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“…These data demonstrated that piRNA/piRNA-L may interact directly with proteins in physiological and pathophysiological conditions. Lee et al [58] recently discovered the direct molecular interaction of piRNA-36026 with target geneserpin peptidase inhibitor, clade A, member 1 (SERPINA1) or lecithin retinol acyltransferase (LRAT), which are two tumor suppressor proteins and subsequent molecular therapeutic responses including caspase-3 and phosphatidyl inositol (PI) in the nucleus by using a piR-36026 molecular beacon (MB).…”

Section: Introductionmentioning

confidence: 99%

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

127

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P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

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“…When piR-360269 expression was inhibited by piR-360269 MB, clear activation signals of caspase-3, LRAT and SERPINA1 were visualized. Hematoxylin and eosin (H&E) stain results displayed that tissue isolated from injection site contains numerous apoptotic tumor cells [49]. As we know, triple-negative breast cancer (TNBC) is an aggressive, poorly-prognostic cancer.…”

Section: Pirnas In Cancermentioning

confidence: 99%

The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms

Han

2019

ExRNA

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More than a decade ago, PIWI-interacting RNA (piRNA) was discovered almost simultaneously by four different research groups. The length of this type of single stranded noncoding RNA is 24~31 nucleotides (nt), with most of the piRNAs fall into the range of 29~30 nt. PiRNAs form specific RNA-induced silencing complex with PIWI subfamily proteins, which is how piRNA got its name. PiRNAs are initially famous for the crucial roles they played in germline cells. Binding with PIWI family proteins, piRNAs is able to affect methylation of genomic DNA in germline cells and, therefore, maintaining genomic stability and suppressing transposons. Since mammalian PIWI subfamily proteins are mainly germline specific, it was once thought that piRNAs might only function in the gonadal cells. However, evidence from the later research suggest that piRNAs are broadly expressed in many kinds of somatic cells and are involved in numerous pathological condition far beyond those have been reported in the germline. For example, piRNAs were discovered to be abnormally expressed in several kinds of cancers. PiRNAs are also shown to be promising prognostic markers for various types of cancers. Interestingly, a recent research indicated that piRNAs are also regulators for pancreatic beta cell function. PiRNAs are promising regulators for the development of type 2 diabetes. From a disease-oriented point of view, this review will focus on both confirmed and proposed biological functions of piRNAs mostly in those fields beyond germline cells. Meanwhile, some of the underlying molecular mechanisms will also be mentioned.

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Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon

Cited by 37 publications

References 52 publications

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms

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