Multiplexed immunosensing of cancer biomarkers on a split-float-gate graphene transistor microfluidic biochip

Wang, Cheng; Wang, Tao; Gao, Yujing; Tao, Qiya; Ye, Weixiang; Jia, Yuan; Zhao, Xiaonan; Zhang, Bo; Zhang, Zhixing

doi:10.1039/d3lc00709j

Cited by 3 publications

(3 citation statements)

References 66 publications

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“…This technology holds promise for detecting various target analytes and integrating data transmission for remote and decentralized analysis and monitoring (Figure 8b). Wang et al 171 developed a microfluidic biochip integrated with a split-float-gate GFET for simultaneous detection of three liver cancer biomarkers (CEA, AFP, PTH). The metal split-float-gate structure overcomes the limitations of the traditional GFET gate electrode, which is restricted to μm 2sized bioaffinity interaction sites.…”

Section: ■ Gfet Integrated In Microfluidic Systemsmentioning

confidence: 99%

“…This technology holds promise for detecting various target analytes and integrating data transmission for remote and decentralized analysis and monitoring (Figure b). Wang et al . developed a microfluidic biochip integrated with a split-float-gate GFET for simultaneous detection of three liver cancer biomarkers (CEA, AFP, PTH).…”

Section: Gfet Integrated In Microfluidic Systemsmentioning

confidence: 99%

mentioning

confidence: 99%

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Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Zhao,

Zhang,

Chen

et al. 2024

ACS Sens.

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The ultrasensitive recognition of biomarkers plays a crucial role in the precise diagnosis of diseases. Graphene-based field-effect transistors (GFET) are considered the most promising devices among the next generation of biosensors. GFET biosensors possess distinct advantages, including label-free, ease of integration and operation, and the ability to directly detect biomarkers in liquid environments. This review summarized recent advances in GFET biosensors for biomarker detection, with a focus on interface functionalization. Various sensitivity-enhancing strategies have been overviewed for GFET biosensors, from the perspective of optimizing graphene synthesis and transfer methods, refinement of surface functionalization strategies for the channel layer and gate electrode, design of biorecognition elements and reduction of nonspecific adsorption. Further, this review extensively explores GFET biosensors functionalized with antibodies, aptamers, and enzymes. It delves into sensitivity-enhancing strategies employed in the detection of biomarkers for various diseases (such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious viruses, etc.) along with their application in integrated microfluidic systems. Finally, the issues and challenges in strategies for the modulation of biosensing interfaces are faced by GFET biosensors in detecting biomarkers.

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Section: ■ Gfet Integrated In Microfluidic Systemsmentioning

confidence: 99%

Section: Gfet Integrated In Microfluidic Systemsmentioning

confidence: 99%

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Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Zhao,

Zhang,

Chen

et al. 2024

ACS Sens.

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2D Materials‐Based Field‐Effect Transistor Biosensors for Healthcare

Li,

Wijaya,

Jang

et al. 2024

Small

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The need for accurate point‐of‐care (POC) tools, driven by increasing demands for precise medical diagnostics and monitoring, has accelerated the evolution of biosensor technology. Integrable 2D materials‐based field‐effect transistor (2D FET) biosensors offer label‐free, rapid, and ultrasensitive detection, aligning perfectly with current biosensor trends. Given these advancements, this review focuses on the progress, challenges, and future prospects in the field of 2D FET biosensors. The distinctive physical properties of 2D materials and recent achievements in scalable synthesis are highlighted that significantly improve the manufacturing process and performance of FET biosensors. Additionally, the advancements of 2D FET biosensors are investigated in fatal disease diagnosis and screening, chronic disease management, and environmental hazards monitoring, as well as their integration in flexible electronics. Their promising capabilities shown in laboratory trials accelerate the development of prototype products, while the challenges are acknowledged, related to sensitivity, stability, and scalability that continue to impede the widespread adoption and commercialization of 2D FET biosensors. Finally, current strategies are discussed to overcome these challenges and envision future implications of 2D FET biosensors, such as their potential as smart and sustainable POC biosensors, thereby advancing human healthcare.

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Novel microfluidic chips integrated with smart devices for in-situ detection of foodborne pathogenic bacteria

Hu,

Wang,

Zheng

et al. 2024

Current Opinion in Food Science

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Multiplexed immunosensing of cancer biomarkers on a split-float-gate graphene transistor microfluidic biochip

Abstract: FET-biosensors have been limited to single-target detections, due to the challenge of assembling multiple receptors within the confined gate area. using a split-float-gate structure, this work realizes the simultaneous detection of multiple analytes.

Cited by 3 publications

References 66 publications

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

2D Materials‐Based Field‐Effect Transistor Biosensors for Healthcare

Novel microfluidic chips integrated with smart devices for in-situ detection of foodborne pathogenic bacteria

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