The main result of this paper is that determinantal point processes on R corresponding to projection operators with integrable kernels are quasi-invariant, in the continuous case, under the group of diffeomorphisms with compact support (Theorem 1.4); in the discrete case, under the group of all finite permutations of the phase space (Theorem 1.6). The Radon-Nikodym derivative is computed explicitly and is given by a regularized multiplicative functional. Theorem 1.4 applies, in particular, to the sine-process, as well as to determinantal point processes with the Bessel and the Airy kernels; Theorem 1.6 to the discrete sineprocess and the Gamma kernel process. The paper answers a question of Grigori Olshanski.