2024
DOI: 10.1177/09622802241293765
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Multiplicative versus additive modelling of causal effects using instrumental variables for survival outcomes – a comparison

Eleanor R John,
Michael J Crowther,
Vanessa Didelez
et al.

Abstract: Instrumental variables (IVs) methods have recently gained popularity since, under certain assumptions, they may yield consistent causal effect estimators in the presence of unmeasured confounding. Existing simulation studies that evaluate the performance of IV approaches for time-to-event outcomes tend to consider either an additive or a multiplicative data-generating mechanism (DGM) and have been limited to an exponential constant baseline hazard model. In particular, the relative merits of additive versus mu… Show more

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