In this article, we deal with the nonlinear Schrödinger equation with nonlocal regional diffusion
false(−normalΔfalse)ραu+Vfalse(xfalse)u=ffalse(x,ufalse)0.30emin0.30emℝN,0.30emu∈Hαfalse(ℝNfalse),
where 0 < α < 1, n ≥ 2, and
f:ℝN×ℝ→ℝ is a continuous function. The operator
false(−normalΔfalse)ρα is a variational version of the nonlocal regional Laplacian defined as
∫ℝN(−Δ)ραu(x)φ(x)dx=∫ℝN∫B(0,ρ(x))[u(x+z)−u(x)][φ(x+z)−φ(x)]|z|N+2αdzdx,
where
ρ∈Cfalse(ℝN,ℝ+false) be a positive function. Considering that ρ, V, and f(· , t) are periodic or asymptotically periodic at infinity, we prove the existence of ground state solution of () by using Nehari manifold and comparison method. Furthermore, in the periodic case, by combining deformation‐type arguments and Lusternik–Schnirelmann theory, we prove that problem () admits infinitely many geometrically distinct solutions.