Multiply resistant Haemophilus influenzae type b causing meningitis: Comparative clinical and laboratory study

Campos, José; García-Tornel, S; Gairi, J M; I, Fabregues

doi:10.1016/s0022-3476(86)80923-4

Cited by 61 publications

(20 citation statements)

References 21 publications

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“…One study mentioned highest rates of ampicillin resistance among children aged less than 5 years, comparable to our findings (Doern et al, 1988). As the outcome of patients with H. influenzae meningitis caused by strains which were resistant to initial therapy consisting of ampicillin and chloramphenicol appeared to be worse in one study, this regimen cannot be recommended now for H. influenzae meningitis in The Netherlands (Campos et al, 1986). Analysis of our N. meningitidis isolates revealed an overall prevalence of intermediate penicillin resistance of 3.3%, comparable to prevalences found in the UK (1980s), USA (1991), and Canada (1991-1992, but far lower than the 20-40% prevalence in Spain (1989Spain ( -1990 (Jones & Sutcliffe, 1990;Saez-Nieto et al, 1992;Jackson et al, 1994;Ringuette et al, 1995).…”

Section: Discussionsupporting

confidence: 86%

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Enting¹,

Spanjaard²,

Beek³

et al. 1996

Journal of Antimicrobial Chemotherapy

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Section: Discussionsupporting

confidence: 86%

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Enting¹,

Spanjaard²,

Beek³

et al. 1996

Journal of Antimicrobial Chemotherapy

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“…Resistance to ampicillin due to a plasmid-mediated extracellular TEM-1 type ß-lactamase was recognized in H. influenzae for the first time in 1974 (7)(8)(9). Subsequently, strains producing a second ß-lactamase named ROB-1 enzyme were reported (10).…”

Section: Introductionmentioning

confidence: 99%

“…More recently, H. influenzae strains referred to as ß-lactamase negative ampicillin resistant (BLNAR) have also been described, although such strains seem to be relatively uncommon as shown by recent national and multinational surveillance studies (2,(11)(12)(13)(14). The prevalence of ampicillin resistance in H. influenzae strains has been the subject of multinational surveillance studies in several countries and the overall rate reported was between 10 and 60% (8,9,(11)(12)(13)(14). The emergence of resistant H. influenzae strains, particularly to ampicillin, all over the world has limited the routine use of ampicillin and as a result third-generation cephalosporins have become a therapeutic option (15,16).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil

Casagrande

Vicente

Landgraf

et al. 2000

Braz J Med Biol Res

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From 1989 to 1995, a total of 391 Haemophilus influenzae isolates were recovered from the cerebrospinal fluid (CSF) of hospitalized patients in São Paulo, Brazil. The majority of strains were isolated from infants aged less than 5 years. Strains belonging to biotype I (64.7%), biotype II (34.5%) and biotype IV (0.76%) were detected. Ninety-nine percent of these strains were serotype b. Minimal inhibitory concentration (MIC) was determined for ampicillin, chloramphenicol and ceftriaxone. The ß-lactamase assay was performed for all strains. The rate of ß-lactamase producer strains ranged from 10 to 21.4% during a period of 7 years, with an overall rate of 13.8%. Of the 391 strains analyzed, none was ß-lactamase negative ampicillin resistant (BLNAR). A total of 9.7% of strains showed resistance to both ampicillin and chloramphenicol; however, 4% of them were resistant to ampicillin only and 2% to chloramphenicol. All strains were susceptible to ceftriaxone and the MIC 90 was 0.007 µg/ml, suggesting that ceftriaxone could be an option for the treatment of bacterial meningitis in pediatric patients who have not been screened for drug sensitivity.

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“…Multiply resistant type b strains have also been encountered including those resistant to both ampicillin and chloramphenicol. Isolation of these latter strains has in general been sporadic (Uchiyama et al 1980;Kenny, Isburg & Michaels, 1980;Simasathien, Duangmani & Echeverria, 1980;Garvey & McMullin, 1983), however, a high prevalance has been observed in Spain (Campos et al 1986). …”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal carriage and antibiotic resistance ofHaemophilus influenzaein healthy children

1988

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SUMMARYAn investigation was undertaken to determine the isolation rate and antibiotic resistance ofHaemophilus influenzae from the nasopharynx of young children. The 996 subjects studied were up to 6 years of age. H. influenzae was isolated from 304 (30 5 %) and strains of capsular type b from 11 (1 1 %). Age, sibling status, season, respiratory infection and antibiotic therapy all influenced isolation rates. The overall prevalence of antibiotic resistance in the strains isolated was ampicillin 5-4% (all fl-lactamase producers), cefaclor 0-3 %, chloramphenicol 1-3%, erythromycin 38-2 %, tetracycline 1 3 %, trimethoprim 5-4 % and sulphamethoxazole 0%. Ampicillin resistance was more common in type b than non-capsulated strains.

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Multiply resistant Haemophilus influenzae type b causing meningitis: Comparative clinical and laboratory study

Cited by 61 publications

References 21 publications

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil

Nasopharyngeal carriage and antibiotic resistance ofHaemophilus influenzaein healthy children

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