Over-wing integration of ultrahigh bypass turbofan engines can be a solution for next-generation commercial transport aircraft since it eliminates the ground clearance issue and it has the potential to reduce ground noise due to acoustic shielding. Moreover, a unique characteristic of this installation type is the powered lift benefit at low-speed flight conditions. This paper aims to experimentally investigate the effect of the engine power setting on the low-speed aerodynamic performance of an over-wing-mounted nacelle configuration comprising a conventional tube-and-wing layout. Thus, low-speed wind tunnel tests were performed for a half-span powered scale model of the aforementioned configuration. The effect of the engine power setting on the wing lift and spanwise pressure distributions was investigated. The experiments were carried out for angles of attack varying from 0 to 6° and inlet mass flow ratios up to 2.4. The results were used to validate computational fluid dynamics simulations conducted for the same wind tunnel conditions. It has been shown that a significant powered lift benefit can be achieved for the studied configuration, without a penalty in the net propulsive force and that the lift increases linearly with the inlet mass flow ratio. Furthermore, it was observed that the engine power setting largely influences the pressure distributions along the wing, especially at the spanwise sections closer to the nacelle. The low-momentum zone created upstream of the engine at high power settings reduces the pressure at the wing’s upper surface, which is the main factor responsible for the increased lift. By taking advantage of such behavior, drag can potentially be reduced at takeoff and climb due to a lower flap setting required for the same lift.