Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

Amoh, Yasuyuki; Li, Lingna; Katsuoka, Kensei; Hoffman, Robert M.

doi:10.4161/cc.7.12.6056

Cited by 141 publications

(123 citation statements)

References 33 publications

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“…However, this is a difficult problem, and although the task is urgent, it will be some time before it is possible to guarantee sufficient safety to enable stem cell use in clinical settings. Prior to any clinical trial of human CNS disorders using iPS cells, it will be essential to pre-evaluate each iPS cell clone carefully to be able to guarantee a safety level equal to other types of cells, such as hair follicle stem cells [45][46][47][48][49][50][51], multipotent skin-derived precursor cells [52,53], fetusderived neural stem/progenitor cells [54], and neural crest stem cells [55]. Moreover, experiments on primates will be essential, as preclinical studies before transplantation can be tried in SCI patients [56].…”

Section: Future Prospects and Tasksmentioning

confidence: 99%

Cell Therapy for Spinal Cord Injury by Neural Stem/Progenitor Cells Derived from iPS/ES Cells

et al. 2011

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Reports of functional recovery from spinal cord injury after the transplantation of rat fetus-derived neural stem cells and embryonic stem cells has raised great expectations for the successful clinical use of stem cell transplantation therapy. However, the ethical issues involved in destroying human embryos or fertilized oocytes to obtain stem cells have been a major obstacle to developing clinically useful stem cell sources, and the transplantation of stem cells isolated from other human embryonic tissues has not yet been developed for use in clinical applications. Recently, induced pluripotent stem cells, which can serve as a source of cells for autologous transplantation, have been attracting a great deal of attention as a clinically viable alternative to stem cells obtained directly from tissues. In this review, we outline the neural induction of mouse embryonic stem cells and induced pluripotent stem cells, their therapeutic efficacy in spinal cord injury, and their safety in vivo.

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Section: Future Prospects and Tasksmentioning

confidence: 99%

Cell Therapy for Spinal Cord Injury by Neural Stem/Progenitor Cells Derived from iPS/ES Cells

et al. 2011

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“…The present study, along with our previous studies of HAP stem cells, [5][6][7][8][9][10][11][12][13]16,17 demonstrate their superiority over ES and iPS cells for regenerative medicine due to HAP stem cells facile accessibility from any patient, their lack of tumorigenicity, lack of the need to insert foreign genes and lack of ethical problems. It is expected in the near future that hHAP stem cells will be the predominant stem cells used for regenerative medicine.…”

Section: Upper Parts Of Human Hair Follicles Form Hhap Stem Cell Colomentioning

confidence: 99%

Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells

et al. 2016

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We have previously demonstrated that nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells are located in the bulge area. HAP stem cells have been previously shown to differentiate to neurons, glial cells, keratinocytes, smooth-muscle cells, melanocytes and cardiac-muscle cells in vitro. Subsequently, we demonstrated that HAP stem cells could effect nerve and spinal cord regeneration in mouse models, differentiating to Schwann cells and neurons. In previous studies, we established an efficient protocol for the differentiation of cardiac-muscle cells from mouse HAP stem cells. In the present study, we isolated the upper part of human hair follicles containing human HAP (hHAP) stem cells. The upper parts of human hair follicles were suspended in DMEM containing 10% FBS where they differentiated to cardiac-muscle cells as well as neurons, glial cells, keratinocytes and smooth-muscle cells. This method is appropriate for future use with human hair follicles to produce hHAP stem cells in sufficient quantities for future heart, nerve and spinal cord regeneration in the clinic.

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“…5 The hair follicle, which cycles through telogen (resting), anagen (growing), and catagen (regression) throughout the life of mammals, undergoes obvious age-related changes including hair loss. 6 The hair follicle contains hair-follicle-associated pluripotent (HAP) stem cells, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] which may also deteriorate during aging.…”

Section: Introductionmentioning

confidence: 99%

Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

Cao

Kajiura

et al. 2016

Cell Cycle

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We demonstrate in the present study that young host mice rejuvenate aged hair follicles after transplantation. Young mice promote the hair shaft growth of transplanted old hair follicles, as well as young follicles, in contrast to old host mice, which did not support hair-shaft growth from transplanted old or young follicles. Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells of transplanted old and young hair follicles remained active in young host nude mice. In contrast, the nestin-expressing HAP stem cells in young and old hair follicles transplanted to old nude mice were not as active as in young nude host mice. The present study shows that transplanted old hair follicles were rejuvenated by young host mice, suggesting that aging may be reversible.

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Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

Cited by 141 publications

References 33 publications

Cell Therapy for Spinal Cord Injury by Neural Stem/Progenitor Cells Derived from iPS/ES Cells

Cell Therapy for Spinal Cord Injury by Neural Stem/Progenitor Cells Derived from iPS/ES Cells

Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells

Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

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