Multipotent Mesenchymal Stromal Cells: Clinical Applications and Cancer Modeling

García‐Castro, Javier; Trigueros, César; Arranz, Mariano García; Menéndez, Pablo

doi:10.1007/978-1-4614-2098-9_13

Cited by 31 publications

(20 citation statements)

References 131 publications

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“…Nowadays, there are several surgical techniques that include the direct repair (Matsuyama et al, 2000), neurotization (Karol, 2003) and nerve grafting (Mafi et al, 2012). Most of these reconstruction strategies, however, have met with only modest success (Matsuyama et al, 2000;Rodriguez et al, 2012). Therefore, recent advances in nanotechnology and tissue engineering have attracted much interest to possibly provide feasible solutions for a broad range of applications in regenerative medicine and to help designing more effective strategies for anatomical and functional repair (Subramanian et al, 2009).…”

Section: Potential Of Msc In the Treatment Of Peripheral Nerve Injurymentioning

confidence: 99%

Wharton's jelly derived mesenchymal stromal cells: Biological properties, induction of neuronal phenotype and current applications in neurodegeneration research

et al. 2015

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Section: Potential Of Msc In the Treatment Of Peripheral Nerve Injurymentioning

confidence: 99%

Wharton's jelly derived mesenchymal stromal cells: Biological properties, induction of neuronal phenotype and current applications in neurodegeneration research

et al. 2015

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“…Simultaneously, these CAF-like MSC also promote tumor cell growth both, in vitro and in an in vivo co-implantation model [135]. Likewise, MSC transformed with specific mutations play an important role in sarcoma genesis and in the control of sarcoma tumor growth [136,137]. Furthermore, MSC which have been isolated from primary breast cancer tissues significantly promote tumor growth and size following co-transplantation with breast cancer cells.…”

Section: Interaction Of Msc With Tumor Cells and A Tumorigenic Microementioning

confidence: 99%

Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment

2012

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Mesenchymal stem cells (MSC) represent a heterogeneous population exhibiting stem cell-like properties which are distributed almost ubiquitously among perivascular niches of various human tissues and organs. Organismal requirements such as tissue damage determine interdisciplinary functions of resident MSC including self-renewal, migration and differentiation, whereby MSC support local tissue repair, angiogenesis and concomitant immunomodulation. However, growth of tumor cells and invasion also causes local tissue damage and injury which subsequently activates repair mechanisms and consequently, attracts MSC. Thereby, MSC exhibit a tissue-specific functional biodiversity which is mediated by direct cell-to-cell communication via adhesion molecule signaling and by a tightly regulated exchange of a multifactorial panel of cytokines, exosomes, and micro RNAs. Such interactions determine either tumor-promoting or tumor-inhibitory support by MSC. Moreover, fusion with necrotic/apoptotic tumor cell bodies contributes to re-program MSC into an aberrant phenotype also suggesting that tumor tissue in general represents different types of neoplastic cell populations including tumor-associated stem cell-like cells. The present work summarizes some functional characteristics and biodiversity of MSC and highlights certain controversial interactions with normal and tumorigenic cell populations, including associated modulations within the MSC microenvironment.

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“…Thus, in vivo models capable of integrating both the nature of the target cell for transformation, the underlying oncogenic lesions, and the influence of the microenvironment will constitute a valuable model to study tumor biology and to assess potential novel therapeutic approaches [48]. Solid evidence indicates that MSCs and/or MSC-derived progenitors represent the TIC for human sarcomas [1][2][3][4]. Likewise, normal, nonmalignant MSC-like cells have been isolated at high frequencies from primary OS samples, suggesting that normal MSCs could be recruited to the microenvironment of OS and play a role in the development of the disease [49].…”

Section: Discussionmentioning

confidence: 99%

“…Over the last years, mesenchymal stromal/ stem cells (MSCs) and/or MSC-derived lineagespecific progenitors have been proposed as the cell of origin for certain soft tissue sarcomas (STS) and primary bone sarcomas [1][2][3][4]. Within bone sarcomas, osteosarcoma (OS) constitutes the most frequent one comprising approximately 20% of new diagnosis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells

et al. 2014

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The cellular microenvironment plays a relevant role in cancer development. We have reported that mesenchymal stromal/stem cells (MSCs) deficient for p53 alone or together with RB (p53) originate leiomyosarcoma after subcutaneous (s.c.) inoculation. Here, we show that intrabone or periosteal inoculation of p53 2/2 or p53 2/2 RB 2/2 bone marrow-or adipose tissue-derived MSCs originated metastatic osteoblastic osteosarcoma (OS). To assess the contribution of bone environment factors to OS development, we analyzed the effect of the osteoinductive factor bone morphogenetic protein-2 (BMP-2) and calcified substrates on p53MSCs. We show that BMP-2 upregulates the expression of osteogenic markers in a WNT signaling-dependent manner. In addition, the s.c. coinfusion of p53 MSCs were inoculated embedded in a calcified ceramic scaffold composed of hydroxyapatite and tricalciumphosphate (HA/TCP), tumoral bone formation was observed in the surroundings of the HA/TCP scaffold. Moreover, the addition of BMP-2 to the ceramic/MSC implants further increased the tumoral osteoid matrix. Together, these data indicate that bone microenvironment signals are essential to drive OS development.

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Multipotent Mesenchymal Stromal Cells: Clinical Applications and Cancer Modeling

Cited by 31 publications

References 131 publications

Wharton's jelly derived mesenchymal stromal cells: Biological properties, induction of neuronal phenotype and current applications in neurodegeneration research

Wharton's jelly derived mesenchymal stromal cells: Biological properties, induction of neuronal phenotype and current applications in neurodegeneration research

Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment

Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells

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