Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

Yamane, Kyoko; Misawa, Haruo; Takigawa, Tomoyuki; Ito, Yoshihiro; Ozaki, Toshifumi; Matsukawa, Akihiro

doi:10.3390/ijms20236078

Cited by 15 publications

(6 citation statements)

References 51 publications

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“…The identification of the HGF locus appears to be in line with these independent results. Indeed, the protein product of the HGF gene is a neurotrophic growth factor that exerts pleiotropic effects on the central nervous system 51 . Further studies will be needed to understand the role of the HGF locus in gene-by-environment interactions related to suicidality.…”

Section: Discussionmentioning

confidence: 99%

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

et al. 2021

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Substance dependence diagnoses (SDs) are important risk factors for suicidality. We investigated the associations of multiple SDs with different suicidality outcomes, testing how genetic background moderates these associations. The Yale-Penn cohort (N = 15,557) was recruited to investigate the genetics of SDs. The Army STARRS (Study to Assess Risk and Resilience in Servicemembers) cohort (N = 11,236) was recruited to evaluate mental health risk and resilience among Army personnel. We applied multivariate logistic regression to investigate the associations of SDs with suicidality and, in the Yale-Penn cohort, we used the structured linear mixed model (StructLMM) to study multivariate gene–environment interactions. In Yale-Penn, lifetime polysubstance dependence was strongly associated with lifetime suicidality: having five SDs showed an association with suicidality, from odds ratio (OR) = 6.77 (95% confidence interval, CI = 5.74–7.99) for suicidal ideation (SI) to OR = 3.61 (95% CI = 2.7–4.86) for suicide attempt (SA). In Army STARRS, having multiple substance use disorders for alcohol and/or drugs was associated with increased suicidality ranging from OR = 2.88 (95% CI = 2.6–3.19) for SI to OR = 3.92 (95% CI = 3.19–4.81) for SA. In Yale-Penn, we identified multivariate gene–environment interactions (Bayes factors, BF > 0) of SI with respect to a gene cluster on chromosome 16 (LCAT, p = 1.82 × 10–7; TSNAXIP1, p = 2.13 × 10−7; CENPT, p = 2.32 × 10−7; PARD6A, p = 5.57 × 10−7) for opioid dependence (BF = 12.2), cocaine dependence (BF = 12.1), nicotine dependence (BF = 9.2), and polysubstance dependence (BF = 2.1). Comorbidity of multiple SDs is a significant associated with suicidality and heritability of suicidality is partially moderated by multivariate gene interactions.

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Section: Discussionmentioning

confidence: 99%

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

et al. 2021

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“…At present, there are many clinical treatments for SCI, such as timely decompression [4,5], methylprednisolone [6], stem cell transplant [7,8], nerve growth factor therapy [9,10], and spinal cord electrical stimulation therapy [11]. Acute spinal cord injury is mainly treated by surgery, which limits the scope of the injury and reduces secondary injury as much as possible; however, functional reconstruction during the recovery period determines the patient's prognosis and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture for Spinal Cord Injury: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Tan

Meng

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Previous studies have shown that electroacupuncture (EA) has a positive effect on motor and sensory function in patients with spinal cord injury (SCI). This review evaluated the effectiveness of EA for improvement in activities of daily living in patients with SCI. Methods. We searched the Cochrane Library, PubMed, Web of Science, CNKI, WanFang Data, and VIP databases using a search strategy according to the guidelines of the Cochrane Handbook for Systematic Review of Interventions up to 30th September 2020. Only randomized controlled trials (RCTs) of EA in patients with SCI were included. We analyzed the data using RevMan (version 5.3) and graded the quality of evidence using GRADE profiler 3.6.1. Results. This meta-analysis included 10 RCTs with 712 patients. Three studies revealed that the functional independence measure score for SCI patients in the EA group was higher than that in the control group (mean difference [MD] = 13.46, 95% CI: 8.00 to 18.92, P < 0.00001 ). Five studies showed that the modified Barthel index in the EA group was higher than that in the control group (MD = 6.92, 95% CI: 4.96 to 8.89, P < 0.00001 ). Five studies showed that the American Spinal Injury Association-motor score (ASIA-motor score) in the EA group was higher than that in the control group (standard MD = 0.96, 95% CI: 0.75 to 1.18, P < 0.00001 ). Three studies reported the ASIA-tactile and pain scores and also reported that the scores in the EA group were higher than those in the control group, with high homogeneity (tactile I2 = 86%, P = 0.0008; pain I2 = 54%, P = 0.11). The quality of evidence for the use of EA for improvement in motor and sensory function in SCIs was moderate according to the GRADE system. Conclusion. This review suggested that EA improves activities of daily living and motor function in patients with SCI, with a moderate level of evidence.

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“…This information is potentially informative in predicting differential responses to cues in the spinal cord environment. We first assembled a list of ligands of interest, based on neurotrophins, growth factors, and axon guidance cues that are either endogenous to spinal cord tissue or which have been exogenously applied in experimental paradigms of spinal injury (Badhiwala et al, 2018; Dun and Parkinson, 2017; Gao et al, 2019; Giger et al, 2010; Goldshmit et al, 2011; Haenzi and Moon, 2017; Hata et al, 2006; Kitamura et al, 2019; Liu et al, 2017; Rosich et al, 2017; Walker and Xu, 2018; Yamane et al, 2019). We then examined the expression of various receptors for each cue across different subtypes of supraspinal neurons ( Figure 9B ).…”

Section: Resultsmentioning

confidence: 99%

Single nuclei analyses reveal transcriptional profiles and marker genes for diverse supraspinal populations

Beine

Wang

Tsoulfas

et al. 2022

Preprint

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The mammalian brain contains numerous neurons distributed across forebrain, midbrain, and hindbrain that project axons to the lower spinal cord and work in concert to control movement and achieve homeostasis. Extensive work has mapped the anatomical location of supraspinal cell types and continues to establish specific physiological functions. The patterns of gene expression that typify and distinguish these disparate populations, however, are mostly unknown. Here we combined retrograde labeling of supraspinal cell nuclei with fluorescence activated nuclei sorting and single nuclei RNA sequencing analyses to transcriptionally profile neurons that project axons from the mouse brain to lumbar spinal cord. We identified fourteen transcriptionally distinct cell types and used a combination of established and newly identified marker genes to assign an anatomical location to each. To validate the putative marker genes, we visualized selected transcripts and confirmed selective expression within lumbar-projecting neurons in discrete supraspinal regions. Finally, we illustrate the potential utility of these data by examining the expression of transcription factors that distinguish different supraspinal cell types and by surveying the expression of receptors for growth and guidance cues that may be present in the spinal cord. Collectively these data establish transcriptional differences between anatomically defined supraspinal populations, identify a new set of marker genes of use in future experiments, and provide insight into potential differences in cellular and physiological activity across the supraspinal connectome.

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Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

Cited by 15 publications

References 51 publications

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Electroacupuncture for Spinal Cord Injury: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Single nuclei analyses reveal transcriptional profiles and marker genes for diverse supraspinal populations

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