Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma

Motley, Richard; Kersey, Peter; Lawrence, C.M.

doi:10.1016/s0007-1226(03)00028-6

Cited by 161 publications

(154 citation statements)

References 73 publications

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“…Although surgical excision is also the primary treatment for SCC, current guidelines require a wider margin (range 4 mm -3 cm) than PTT [9,15]. Additionally, due to the fact that the raphe of the scrotum does not provide a physical barrier to scrotal lymphatic drainage and that the scrotum has bilateral inguinal drainage, secondary treatments such as (1) inguinal sentinel lymph node dissection (ILND) / subsequent complete ILND in cases with clinical or histologic evidence for regional spread of disease and (2) palliative chemotherapy for locally advanced and metastatic disease are advocated for SCC [15,2,16]. It is important for clinicians to be aware of PTT as an entity when discussing the differential diagnosis of scrotal masses, as it can be clinically and histologically confused with the more common SCC of the scrotum and has significantly different prognostic and treatment ramifications.…”

Section: Discussionmentioning

confidence: 99%

Proliferating Trichilemmal Tumor Presenting as a Scrotal Mass in a Middle-Aged Male: An Uncommon Location

Aldulescu¹

2017

CDOAJ

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Scrotal masses encompass a heterogenous group of conditions affecting the skin and soft tissue of the scrotum or underlying testis, ranging from benign to malignant and from indolent to conditions requiring urgent medical evaluation.Accurate and timely diagnosis is imperative with scrotal masses, as the medical ramifications of different diagnoses vary widely, and the social and psychological implications can be significant. Here we present the first reported case of a middle-aged male with an enlarging scrotal/extra-testicular mass, which upon excision, was found to be consistent with a proliferating trichilemmal tumor, a benign neoplasm derived from outer root sheath of the hair follicle which has a strong capacity to simulate squamous cell carcinoma. Distinguishing between these two entities is of utmost importance due to their significantly different prognostic and treatment ramifications, and ultimately directs appropriate management of these patients.

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Section: Discussionmentioning

confidence: 99%

Proliferating Trichilemmal Tumor Presenting as a Scrotal Mass in a Middle-Aged Male: An Uncommon Location

Aldulescu¹

2017

CDOAJ

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“…18 Follow up is very important to detect recurrence or persistence of the tumor and presence of new lesion.…”

Section: Discussionmentioning

confidence: 99%

A precancerous saree lesion: a rare occurrence

2015

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<p class="abstract"><span lang="EN-US">Skin cancers are relatively uncommon malignancies; their incidence in India being less than 1% of all cancers. The incidence of malignancy in scar tissues is 0.1-2.5%. Squamous cell carcinoma of skin is second most common amelanotic malignancy next to basal cell carcinoma. The occurrence of this disease is noticed in various parts of the body but waist line skin is not a common site. Saree is a type of female costume and dhoti is a male costume which is unique to the Indian subcontinent. The persistent and long term wearing of this costume results in depigmentation and glazing of the skin, acanthosis, dysplasia, scar and ulceration and subsequent, but very slow, malignant changes. The exact mechanism of the malignant transformation is unknown, but recurrent trauma over a long period with consequent interference with the healing process is a possible explanation. We are presenting a rare case of left flank ulcero-proliferative growth in a 75 year old woman. Wide excision with primary skin closure was done. Histopathology showed pseudoepitheliomatous hyperplasia with marked dysplasia without microinvasion. It is a premalignant lesion. The case needs its reporting due to its rarity. Awareness of saree cancer among Indians is important to prevent malignant lesions at waistline. Multimodality management with surgery, chemotherapy and radiotherapy is ideal for good outcome.</span></p>

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“…53,54 European consensus recommendations of 10 mm in high-risk disease have also been proposed. 55 Caution should be applied to ensure that the deep excision margin extends to the hypodermis, macroscopically deep to tumor, as the majority of positive margins occur at the deep margin.…”

Section: Conventional Surgical Excisionmentioning

confidence: 99%

High-risk Cutaneous Squamous Cell Carcinoma

Fitzgerald¹,

O’Neill²

2017

International Journal of Head and Neck Surgery

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Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer worldwide. Cutaneous squamous cell carcinoma can potentially be treated fully with minimal morbidity when detected early; however, certain subtypes of cSCC have been shown to confer a poorer prognosis for patients. In these high-risk tumors, increased incidence of recurrence, as well as metastasis to local lymph nodes and distant sites, is seen as a result of certain patient characteristics and pathological features. While guidelines regarding the management of high-risk cSCC have been produced, no clear consensus management or prognostic algorithms exist. In this review, we discuss current definitions of high-risk cSCC, recommendations regarding the management of cSCC, and current guidelines.

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Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma

Cited by 161 publications

References 73 publications

Proliferating Trichilemmal Tumor Presenting as a Scrotal Mass in a Middle-Aged Male: An Uncommon Location

Proliferating Trichilemmal Tumor Presenting as a Scrotal Mass in a Middle-Aged Male: An Uncommon Location

A precancerous saree lesion: a rare occurrence

High-risk Cutaneous Squamous Cell Carcinoma

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