Multipurpose and Durable Adhesive Hydrogel Assisted by Adenine and Uracil from Ribonucleic Acid

Abstract

Nucleobase pairs of adenine and uracil (A-U) from ribonucleic acid are of particular interest for various promising material properties. Herein, a novel polyacrylamide hydrogel with adhesive properties that are assisted by adenine and uracil has been designed and investigated. The incorporation of adenine and uracil enables the formation of a polyacrylamide hydrogel with remarkable adhesive behaviour with various materials including polytetrafluoroethylene (PTFE), plastics, rubber, glasses, metal, ceramics and wood. Moreover, the adhesive hydrogel can easily and directly adhere to humid biological tissues without any extra process, including heart, liver, spleen, lung, kidney, bone and muscle of mouse. More impressively, even after repeated peeling tests (10×), the AU-mediated polyacrylamide hydrogel still exhibits excellent durable adhesion for various materials. From mechanical contact tests, the adhesion energy of the A-U adhesive hydrogel is 47.9 J m , which is nearly nine times that of polyacrylamide hydrogel (5.3 J m ). The 90° peeling strength for aluminium, titanium, silica rubbers, glasses, PTFE and hogskin is 518, 645, 445, 396, 349, and 119 N m , respectively. The multipurpose and durable adhesive behaviour of hydrogels assisted by adenine and uracil indicated the promise of nucleobase pairs from ribonucleic acid for the future development of adhesive materials.

Ultrastretchable Wearable Strain and Pressure Sensors Based on Adhesive, Tough, and Self-healing Hydrogels for Human Motion Monitoring

“…As the contact time increases, the peel strength of the SC–PDA hydrogel increases significantly, and the maximum adhesion strength reaches 2200 N/m after adhering for 30 min. Moreover, the comparison of interfacial adhesion energy for various adhesive materials is also summarized in Figure b. ,,− The adhesion energy of the SC–PDA hydrogel was significantly superior than that of other adhesive hydrogels, biological tissues, and commercial tapes. Also, this wide range of interface bonding energy will greatly satisfy practical applications.…”

Highly Tough, Stretchable, Self‐Adhesive and Strain‐Sensitive DNA‐Inspired Hydrogels for Monitoring Human Motion

“…And for the Tba, the FTIR band at 1204 cm −1 is ascribed to the stretching vibration of C−O (Figure S2), which both demonstrated the successful synthesis of Aba and Tba. Here, Aba and Tba, not only act as physical crosslinkers through intermolecular interactions, but also provide special adhesion through multiple hydrogen bonding interactions with different substrates …”

“…Here, Aba and Tba, not only act as physical crosslinkers through intermolecular interactions, but also provides pecial adhesion through multiple hydrogen bonding interactions with different substrates. [31,32,37,38]…”

Freezing-Tolerant, Nondrying, Stretchable, and Adhesive Organohydrogels Inspired by the DNA Double Helix Structure for a Flexible Dual-Response Sensor

“…Driven by hydrogen bonding, base pairs are formed between the paired purines and pyrimidines [i.e., adenine-thymine/uracil (A-T/U), guanine-cytosine (G-C)]; these base pairs are matched with high degrees of accuracy and directionality. , Due to the unique molecular structure, base molecules can interact with different kinds of substrates through hydrogen bonding, metal complexation, and hydrophobic interaction . Hence, amino-rich bases can serve as adhesion factors that endow the materials with good adhesive behaviors; such materials are potentially useful in the fields of multifunctional self-healing adhesives, light-emitting diodes, , and biomedical polymers . Moreover, the bases containing abundant amino groups can bind a water molecule through hydrogen bonds, which are able to effectively avoid the solvent evaporation.…”