Multipurpose Antifouling Coating of Solid Surfaces with the Marine‐Derived Polymer Fucoidan

Jeong, Yeonwoo; Thủy, Lê Thị Thanh; Ki, So Hyun; Ko, Sangwon; Kim, Suyeob; Cho, Woo Kyung; Choi, Joon Sig; Kang, Sung Min

doi:10.1002/mabi.201800137

Cited by 32 publications

(31 citation statements)

References 61 publications

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“…This ability to disrupt cell–cell interactions is likely at least in part, responsible for the potent anti-inflammatory activity of different fucoidan preparations [1]. Fucoidans can also inhibit the adhesion of proteins and organisms to non-biological surfaces, and may help to inhibit biofouling [4]. The anti-microbial activity of fucoidans is also largely based on its inhibition of bacteria-substrate binding [5].…”

Section: Introductionmentioning

confidence: 99%

Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen

et al. 2019

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Fucoidan, the sulfated fucose-rich polysaccharide derived from brown macroalgae, was reported to display some anti-cancer effects in in vitro and in vivo models that included apoptosis and cell cycle arrest. The proposed mechanisms of action involve enhanced immune surveillance and direct pro-apoptotic effects via the activation of cell signaling pathways that remain largely uncharacterized. This study aimed to identify cellular pathways influenced by fucoidan using an unbiased genetic approach to generate additional insights into the anti-cancer effects of fucoidan. Drug–gene interactions of Undaria pinnatifida fucoidan were assessed by a systematic screen of the entire set of 4,733 halpoid Saccharomyces cerevsiae gene deletion strains. Some of the findings were confirmed using cell cycle analysis and DNA damage detection in non-immortalized human dermal fibroblasts and colon cancer cells. The yeast deletion library screen and subsequent pathway and interactome analysis identified global effects of fucoidan on a wide range of eukaryotic cellular processes, including RNA metabolism, protein synthesis, sorting, targeting and transport, carbohydrate metabolism, mitochondrial maintenance, cell cycle regulation, and DNA damage repair-related pathways. Fucoidan also reduced clonogenic survival, induced DNA damage and G1-arrest in colon cancer cells, while these effects were not observed in non-immortalized human fibroblasts. Our results demonstrate global effects of fucoidan in diverse cellular processes in eukaryotic cells and further our understanding about the inhibitory effect of Undaria pinnatifida fucoidan on the growth of human cancer cells.

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Section: Introductionmentioning

confidence: 99%

Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen

et al. 2019

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“…Immobilised fucoidans on a variety of surfaces have also assisted in bone regeneration models [50] and in the prevention of coagulation [51]. A materials science application for fucoidans, in the form of immobilised fucoidan on steel surfaces, has potential to inhibit the surface adhesion and transfer of infectious agents and inhibit biofouling [52]. This novel approach may have utility in coating surgical instruments and implantable devices.…”

Section: Biomaterials and Drug Deliverymentioning

confidence: 99%

Therapies from Fucoidan: New Developments

Fitton¹,

Stringer²,

Park³

et al. 2019

Marine Drugs

136

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Since our last review in 2015, the study and use of fucoidan has extended in several research areas. Clinical use of fucoidan for the treatment of renal disease has become available and human safety studies have been undertaken on radiolabeled fucoidan for the purpose of imaging thrombi. Fucoidan has been incorporated into an increasing number of commercially available supplements and topical treatments. In addition, new measuring techniques are now available to assess the biologically relevant uptake of fucoidans and to assist in production. Microbiome modulation and anti-pathogenic effects are increasingly promising applications for fucoidans, due to the need for alternative approaches to antibiotic use in the food chain. This review outlines promising new developments in fucoidan research, including potential future therapeutic use.

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“…This ability to disrupt cell-cell interactions is likely, at least in part, responsible for the potent anti-inflammatory activity of different fucoidan preparations. Fucoidans can also inhibit the adhesion of proteins and organisms to non-biological surfaces, and may help to inhibit biofouling [3]. Previous data using a yeast deletion library illustrated that fucoidans can interact with more fundamental cellular pathways than previously anticipated [4].…”

Section: Introductionmentioning

confidence: 99%

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

et al. 2020

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Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.

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Multipurpose Antifouling Coating of Solid Surfaces with the Marine‐Derived Polymer Fucoidan

Cited by 32 publications

References 61 publications

Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen

Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen

Therapies from Fucoidan: New Developments

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

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