Multipurpose Intraperitoneal Adhesive Patches

Ryu, Ji Hyun; Kim, Hye Jin; Kim, Kyuri; Yoon, Ghil-Suk; Wang, Younseon; Choi, Gyu–Seog; Lee, Haeshin; Park, Jun Seok

doi:10.1002/adfm.201900495

Cited by 38 publications

(26 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adhesive hydrogels can be realized by tuning the chemical bonding and mechanics of energy dissipation [20]. Various adhesive hydrogels have been reported using different adhesion strategies, such as host-guest [21][22][23], nucleobase [24], and energy dissipative matrix [25].…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Redox-Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics

et al. 2020

View full text Add to dashboard Cite

Conductive polymers (CPs) are generally insoluble, and developing hydrophilic CPs is significant to broaden the applications of CPs. In this work, a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles (CP NPs), while endowing the CP NPs with redox activity and biocompatibility. This is a universal strategy applicable for a series of CPs, including polyaniline, polypyrrole, and poly(3,4-ethylenedioxythiophene). The catechol/quinone contained sulfonated lignin (LS) was doped into various CPs to form CP/LS NPs with hydrophilicity, conductivity, and redox activity. These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness. The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network, forming a well-connected electric path. The hydrogel exhibits long-term adhesiveness, which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs. This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics.

show abstract

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Redox-Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Insufficient contact produces a gap where a water molecule stays and reduces surface energy of the substrate which is the most important driving force for tough bonding [ 9 , 10 , 11 , 12 , 13 ]. The host-guest strategy was reported to prepare underwater adhesive after modifying the surface of substrates in advance [ 14 ], however, most of these adhesives cannot bind strongly without preprocessing the substrates [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Hotmelt Adhesives with Well-Adhesion in Water

Dong

Zhuang

et al. 2021

Polymers

View full text Add to dashboard Cite

We suggest a simple idea of bio-based adhesives with strong adhesion even under water. The adhesives simply prepared via polycondensation of 3,4-dihydroxyhydrocinnamic acid (DHHCA) and lactic acid (LA) in one pot polymerization. Poly(DHHCA-co-LA) has a hyperbranched structure and demonstrated strong dry and wet adhesion strength on diverse material surfaces. We found that their adhesion strength depended on the concentration of DHHCA. Poly(DHHCA-co-LA) with the lowest concentration of DHHCA showed the highest adhesion strength in water with a value of 2.7 MPa between glasses, while with the highest concentration of DHHCA it exhibited the highest dry adhesion strength with a value of 3.5 MPa, which was comparable to commercial instant super glue. Compared to underwater glues reported previously, our adhesives were able to spread rapidly under water with a low viscosity and worked strongly. Poly(DHHCA-co-LA) also showed long-term stability and kept wet adhesion strength of 2.2 MPa after steeping in water for 1 month at room temperature (initial strength was 2.4 MPa). In this paper, Poly(DHHCA-co-LA) with strong dry and wet adhesion properties and long-term stability was demonstrated for various kinds of applications, especially for wet conditions.

show abstract

“…Hydrogels with strong adhesion capabilities can eliminate the need for external aids, facilitating comfortable wear experience, conformal contact with the tissues, and reliable and stable performance [ [7] , [8] , [9] ]. The adhesive hydrogels can be designed by considering the synergistic effects of chemistry, topology, and mechanics [ 10 , 11 ]. Various adhesive hydrogels have been developed based on different adhesion strategies, such as supramolecular-based adhesives, hydrogen bonds, nucleobases, and topological adhesive hydrogels [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Jia

Hou

et al. 2021

Bioactive Materials

160

120

View full text Add to dashboard Cite

Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.

show abstract

Multipurpose Intraperitoneal Adhesive Patches

Cited by 38 publications

References 67 publications

Mussel-Inspired Redox-Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics

Mussel-Inspired Redox-Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics

Bio-Based Hotmelt Adhesives with Well-Adhesion in Water

Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Contact Info

Product

Resources

About