“…Twenty-one studies found shortcomings relating not only to ethical, legal, and regulatory issues but also to security, confidentiality, and privacy. They also noted that limitations existed regarding interoperability and compatibility between systems using TH [ 2 , 7 , 12 , 15 , 16 , 17 , 19 , 21 , 23 , 27 , 28 , 33 , 35 , 36 , 37 , 38 , 40 , 42 , 45 , 46 ]. Besides these shortcomings, the impact of which means that such technologies run into complex implementation difficulties, there is a need for more studies to investigate how significant improvements could be achieved in the clinical efficacy and cost-efficiency associated with their use.…”