Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography–tandem mass spectrometry

Piątkowska, Marta; Jedziniak, Piotr; Żmudzki, J.

doi:10.1016/j.foodchem.2015.10.076

Cited by 77 publications

(38 citation statements)

References 30 publications

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“…The analytical techniques reported in the literature for the monitoring and determination of tetracycline antibiotics and other veterinary drugs in eggs are mostly chromatographic, including high performance liquid chromatography (HPLC) with ultraviolet (UV) [7,[11][12][13], fluorescence [14], or mass spectrometry (MS/MS) [1][2][3][4][15][16][17][18][19][20] detection, and ultrahigh-pressure liquid chromatography-tandem mass spectrometry (UHPL-MS/MS) [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The most important are solvent extraction [5,16], liquid-liquid extraction (LLE) [3], solidphase extraction (SPE) [1,2,4,5,11,14,15,17,19], ultrasonic-assisted extraction (UAE) [2], and pressurized liquid extraction (PLE) [6,12]. Furthermore, SPE modifications using molecularly imprinted solid-phase extraction (MISPE) [13,20] and magnetic molecularly imprinted polymer solidphase extraction (MIP-SPE) [18] have also been used as extraction methods.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Pérez-Rodríguez

Pezza

2016

Anal Bioanal Chem

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A simple, rapid, and efficient ultrasound-assisted dispersive liquid-liquid microextraction (US-DLLME) method was developed for extraction of tetracycline residues from egg supplement samples, with subsequent determination by flow injection analysis (FIA) coupled to a liquid waveguide capillary cell (LWCC) and a controlled temperature heating bath. Tetracyclines react with diazotized p-sulfanilic acid, in a slightly alkaline medium, to form azo compounds that can be measured at 435 nm. The reaction sensitivity improved substantially (5.12-fold) using an in-line heating temperature of 45 °C. Multivariate methodology was used to optimize the factors affecting the extraction efficiency, considering the volumes of extraction and disperser solvents, sonication time, extraction time, and centrifugation time. Good linearity in the range 30-600 μg L(-1) was obtained for all the tetracyclines, with regression coefficients (r) higher than 0.9974. The limits of detection ranged from 6.4 to 11.1 μg L(-1), and the recoveries were in the range 85.7-96.4 %, with relative standard deviation lower than 9.8 %. Analyte recovery was improved by approximately 6 % when the microextraction was assisted by ultrasound. The results obtained with the proposed US-DLLME-FIA method were confirmed by a reference HPLC method and showed that the egg supplement samples analyzed were suitable for human consumption.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Pérez-Rodríguez

Pezza

2016

Anal Bioanal Chem

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“…Several studies have been conducted using micellar liquid detection, biosensor immunoassay (BIA), and capillary electrophoresis coupled with mass spectrometry to analyze flumequine in the environment, food, and animals. These methods lack sensitivity and require extensive sample preparation, such as derivatization before analysis.…”

Section: Introductionmentioning

confidence: 99%

“…These methods lack sensitivity and require extensive sample preparation, such as derivatization before analysis. Mass spectrometry (MS) has played an important role in determination due to its sensitivity, rapidity, and requirement of a low amount of sample for characterization and determination …”

Section: Introductionmentioning

confidence: 99%

“…Mass spectrometry (MS) has played an important role in determination due to its sensitivity, rapidity, and requirement of a low amount of sample for characterization and determination. 19,[24][25][26][27] As a result, further studies on the simultaneous analysis of flumequine enantiomers in rat plasma are still necessary due to the absence of a suitable method. The aim of this study was to further develop and validate a selective and specific ultrafast liquid chromatography (UFLC)-electron spray ionization tandem mass spectrometry (ESI-MS/MS) method using propranolol as an internal standard (IS) for the simultaneous determination of flumequine enantiomers in rat plasma.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of flumequine enantiomers in rat plasma by UFLC‐ESI‐MS/MS

Wang

Jin

et al. 2016

Chirality

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In this study the analysis and confirmation of flumequine enantiomers in rat plasma by ultra-fast liquid chromatography coupled with electron spray ionization mass spectrometry (using propranolol as an internal standard [IS]) was developed and validated. Plasma samples were prepared by liquid-liquid extraction using methyl tert-butyl ether as the extraction solvent. Direct resolution of the R- and S-isomers was performed on a CHIRALCEL OJ-RH column (4.6 × 150 mm, 5 μm) using acetonitrile / 0.1% formic acid / 1 mM ammonium acetate as the mobile phase. Detection was operated by electron spray ionization in the selected ion monitoring and positive ion mode. The target ions at m/z 262.1 and m/z 260.1 were selected for the quantification of the enantiomers and IS, respectively. The linear range was 0.5-500 ng/mL. The precisions (coefficient of variation, CV%) and recoveries were 1.43-8.68 and 94.24-106.76%, respectively. The lowest quantitation limit for both enantiomers is 0.5 ng/mL, which is sensitive enough to be applied to sample analysis in other related studies.

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Method Validation and Quality Assurance/Quality Control Approaches for Multi-residue Methods

Cannavan

Kay²,

Jandrić

2016

Chemical Analysis of Non&;#x02010;antimicrobial Veterinary Drug Residues in Food

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Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography–tandem mass spectrometry

Cited by 77 publications

References 30 publications

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Analysis of flumequine enantiomers in rat plasma by UFLC‐ESI‐MS/MS

Method Validation and Quality Assurance/Quality Control Approaches for Multi-residue Methods

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