This study focuses on the Sirba River Basin (SRB), a transboundary West African catchment of 38,950 km2 shared by Burkina Faso and Niger, which contributes to flooding downstream in Niamey (Niger). The study uses the HEC-HMS hydrological model to explore the dynamics of the daily rainfall–runoff relationship over the period 2006–2020. The model is calibrated using observed rainfall at 13 meteorological stations within the river basin and observed discharges at the Garbey Kourou hydrometric station outlet. Two types of simulation are compared: (i) a continuous simulation (CS) over the period 2006–2020 and (ii) an event-based simulation (ES) using selected major flood events in 2010, 2012, 2013, 2015 and 2020. The results showed satisfactory model performance under both modeling schemes (R2 = 0.84–0.87 for CS and R2 = 0.94–0.98 for ES), with a superior performance of ES over CS. Also, significant differences in the distribution of calibrated model parameters for the percent impervious and the attenuation flood wave factor were observed. A sensitivity analysis revealed that the curve number, initial abstraction, lag time and routing time factors were influential on the model outputs. The study therefore underscores the model’s robustness and contributes crucial insights for flood control management and infrastructure planning in the SRB.