Flexible endoscopes based on fiber bundles are still widely used despite the recent success of so-called tipchip endoscopes. This is partly due to the costs and that for extremely thin diameters (below 3 mm) there are still only fiberscopes available. Due to the inevitable artifacts caused by the transition from the fiber bundles to the sensor chip, image and texture analysis algorithms are severely handicapped. Therefore, texture-based computer-assisted diagnosis (CAD) systems could not be used in such domains without image preprocessing. We describe a CAD system approach that includes an image filtering algorithm to remove the fiber image artifacts first and then applies conventional color texture algorithms that have been applied to other endoscopic disciplines in the past. The concept is evaluated on an image database with artificially rendered fiber artifacts so that ground truth information is available.