Multiscale Modeling of Angiogenesis

Noren, David; Rekhi, Rahul; Long, Byron L.; Qutub, Amina A.

doi:10.1201/b16777-15

Cited by 1 publication

(2 citation statements)

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“…This task is made easier by the discrete modeling of endothelial cells as agents capable of independent decisions as well as inter-agent actions. Discrete models like this can serve as a framework for the type of module-based modeling previously described142930 which attempt to combine independently validated models of cellular processes as modules in a larger integrated model of angiogenesis, or can be incorporated into other models as processes such as tumor growth or metastatic colonization in which angiogenesis is involved.…”

Section: Discussionmentioning

confidence: 99%

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Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis

Norton

Popel

2016

Sci Rep

125

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Angiogenesis, the recruitment of new blood vessels, is a critical process for the growth, expansion, and metastatic dissemination of developing tumors. Three types of cells make up the new vasculature: tip cells, which migrate in response to gradients of vascular endothelial growth factor (VEGF), stalk cells, which proliferate and extend the vessels, and phalanx cells, which are quiescent and support the sprout. In this study we examine the contribution of tip cell migration rate and stalk cell proliferation rate on the formation of new vasculature. We calculate several vascular metrics, such as the number of vascular bifurcations per unit volume, vascular segment length per unit volume, and vascular tortuosity. These measurements predict that proliferation rate has a greater effect on the spread and extent of vascular growth compared to migration rate. Together, these findings provide strong implications for designing anti-angiogenic therapies that may differentially target endothelial cell proliferation and migration. Computational models can be used to predict optimal anti-angiogenic therapies in combination with other therapeutics to improve outcome.

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Section: Discussionmentioning

confidence: 99%

“…A significant class of studies have been performed in the area of computational modeling of angiogenesis (for reviews see1415) and as it relates specifically to tumor growth (for reviews see161718). The migration of tip cells, both chemotactic and haptotactic, was examined in response to differences in angiogenic factor distributions19.…”

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confidence: 99%