Multiscale modeling of vertebrate limb development

Glimm, Tilmann; Bhat, Ramray; Newman, Stuart A.

doi:10.1002/wsbm.1485

Cited by 11 publications

(5 citation statements)

References 143 publications

(236 reference statements)

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“…Up to 70% of Thorius individuals show left–right asymmetry in the arrangement of carpal or tarsal elements in the limbs and/or anterior elements in the skull, and similar variation exists among individuals ( Hanken 1982 ; Hanken 1984 ). This degree of variability demonstrates that the outcome of precartilage condensation is subject to stochastic noise in the cellular processes involved in cell aggregation (i.e., cell movement, cell–cell adhesion, cell-extracellular matrix interaction) ( Chatterjee et al 2020 ; Glimm et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Metamorphosis Imposes Variable Constraints on Genome Expansion through Effects on Development

Mueller

Cressler

Schwartz

et al. 2023

Integrative Organismal Biology

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Genome size varies ∼ 100,000-fold across eukaryotes and has long been hypothesized to be influenced by metamorphosis in animals. Transposable element accumulation has been identified as a major driver of increase, but the nature of constraints limiting the size of genomes has remained unclear, even as traits such as cell size and rate of development co-vary strongly with genome size. Salamanders, which possess diverse metamorphic and non-metamorphic life histories, join the lungfish in having the largest vertebrate genomes ࣧ 3 to 40 times that of humans ࣧ as well as the largest range of variation in genome size. We tested 13 biologically-inspired hypotheses exploring how the form of metamorphosis imposes varying constraints on genome expansion in a broadly representative phylogeny containing 118 species of salamanders. We show that metamorphosis during which animals undergo the most extensive and synchronous remodeling imposes the most severe constraint against genome expansion, with the severity of constraint decreasing with reduced extent and synchronicity of remodeling. More generally, our work demonstrates the potential for broader interpretation of phylogenetic comparative analysis in exploring the balance of multiple evolutionary pressures shaping phenotypic evolution.

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Section: Discussionmentioning

confidence: 99%

Metamorphosis Imposes Variable Constraints on Genome Expansion through Effects on Development

Mueller

Cressler

Schwartz

et al. 2023

Integrative Organismal Biology

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“…This degree of variability demonstrates that the outcome of precartilage condensation is subject to stochastic noise in the cellular processes involved in cell aggregation (i.e. cell movement, cell-cell adhesion, cell-extracellular matrix interaction) (Chatterjee, et al 2020; Glimm, et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Metamorphosis imposes variable constraints on genome expansion through effects on development

Cressler²,

et al. 2021

Preprint

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Genome size varies ~ 100,000-fold across eukaryotes. Genome size is heavily shaped by transposable element accumulation, the dynamics of which are increasingly well understood. However, given that traits like cell size and rate of development co-vary strongly with genome size, organism-level trait evolution likely shapes genome size diversity as well. Metamorphosis -- a radical transformation of morphology -- has been hypothesized to impact genome size because it can be a vulnerable part of the life cycle. Thus, selection may act to limit metamorphic duration, indirectly constraining the rate of development as well as genome and cell sizes. Salamanders have large and variable genomes -- 3 to 40 times that of humans -- and species exhibit a range of metamorphic and non-metamorphic life histories. Using salamanders, we test the hypothesis that different types of metamorphic repatterning during the life cycle impose different constraints on genome expansion. We show that metamorphosis during which animals are unable to feed imposes the most severe constraint against genome expansion. Other types of metamorphosis that differ in energetic provisioning impose less severe constraints. More generally, our work demonstrates the utility of phylogenetic comparative methods in testing the role of constraint in shaping phenotypic evolution.

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“…Cell division in these models is represented as a volume increase of the fluid [103]. A major benefit of these continuum models is that they can be easily combined with existing models of morphogen diffusion [5,104]. The reaction-diffusion equations can be solved with the mesh representing the mesenchyme.…”

Section: Box 1: Computational Models Of Tissue and Cell Mechanics In ...mentioning

confidence: 99%

Mechanical Regulation of Limb Bud Formation

Sermeus

Vangheel

Geris

et al. 2022

Cells

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Early limb bud development has been of considerable interest for the study of embryological development and especially morphogenesis. The focus has long been on biochemical signalling and less on cell biomechanics and mechanobiology. However, their importance cannot be understated since tissue shape changes are ultimately controlled by active forces and bulk tissue rheological properties that in turn depend on cell–cell interactions as well as extracellular matrix composition. Moreover, the feedback between gene regulation and the biomechanical environment is still poorly understood. In recent years, novel experimental techniques and computational models have reinvigorated research on this biomechanical and mechanobiological side of embryological development. In this review, we consider three stages of early limb development, namely: outgrowth, elongation, and condensation. For each of these stages, we summarize basic biological regulation and examine the role of cellular and tissue mechanics in the morphogenetic process.

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Multiscale modeling of vertebrate limb development

Cited by 11 publications

References 143 publications

Metamorphosis Imposes Variable Constraints on Genome Expansion through Effects on Development

Metamorphosis Imposes Variable Constraints on Genome Expansion through Effects on Development

Metamorphosis imposes variable constraints on genome expansion through effects on development

Mechanical Regulation of Limb Bud Formation

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