Multiscale Modelling of Cancer Progression and Treatment Control: The Role of Intracellular Heterogeneities in Chemotherapy Treatment

Chaplain, M. A. J.; Powathil, Gibin

doi:10.1142/9789814730266_0001

Research on the Physics of Cancer 2016

DOI: 10.1142/9789814730266_0001

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Multiscale Modelling of Cancer Progression and Treatment Control: The Role of Intracellular Heterogeneities in Chemotherapy Treatment

M. A. J. Chaplain

Gibin Powathil

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2022

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Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

Truong

Baverel

Lythe

et al. 2022

CPT Pharmacom & Syst Pharma

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Mathematical models in oncology aid in the design of drugs and understanding of their mechanisms of action by simulation of drug bio-distribution, drug effects, and interaction between tumour and healthy cells. The traditional approach in pharmacometrics is to develop and validate ordinary differential equation models to quantify trends at the population level. In this approach, time-course of biological measurements is modelled continuously, assuming a homogenous population.Another approach, agent-based models focus on the behaviour and fate of biological entities at the individual level which subsequently could be summarized to reflect the population level. Heterogeneous cell populations and discrete events are simulated, and spatial distribution can be incorporated. In this tutorial, an agentbased model is presented and compared to an ordinary differential equation model for a tumour efficacy model inhibiting the pERK pathway. We highlight strengths, weaknesses, and opportunities of each approach.

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Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

Truong

Baverel

Lythe

et al. 2022

CPT Pharmacom & Syst Pharma

View full text Add to dashboard Cite

show abstract

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Multiscale Modelling of Cancer Progression and Treatment Control: The Role of Intracellular Heterogeneities in Chemotherapy Treatment

Cited by 1 publication

References 11 publications

Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

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