Multiscale polymeric fibers for drug delivery and tissue engineering

Developing strategies to optimize the anchorage between electrospun nanofibers and hydrogels for multi-layered plasmonic biomaterials

“…Researchers can optimize various processing parameters, such as voltage, working distance, needle size, and flow rate, to tailor the material's properties to specific needs. 24 Nanofibers have found applications in various biomedical fields, including tissue engineering, 25,26 drug delivery, 27 cell carriers, 28 wound healing, 29 biosensing, 30 etc. They offer a range of advantageous features, including a large surface area, tuneable porosity, a possibility for easy surface functionalization, and sufficient mechanical properties.…”

Development of Poly(methyl methacrylate)/nano-hydroxyapatite (PMMA/nHA) Nanofibers for Tissue Engineering Regeneration Using an Electrospinning Technique

“…Another method is the melt-spinning method, where rapid cooling allows obtaining nanofibers. Another method is coaxial electrospinning, which uses two liquids (e.g., polymer and solution) forced through two separate nozzles, creating fibers with a coaxial structure, as well as others, including force spinning, template synthesis, and drawing [ 15 , 16 , 17 ]. Overall, although other nanofiber formation methods exist, electrospinning remains the preferred choice for tissue engineering applications due to its versatility, scalability, and ability to produce nanofiber scaffolds with tailored properties to support tissue regeneration.…”

Nanofiber Hydrogel Drug Delivery System for Prevention of Postsurgical Intestinal Adhesion

“…22−24 Due to their dual function as barriers and drug transporters, biomaterials have received considerable attention in preventing PIAs. 25,26 Biomaterials engineered with micro-or nanosized structures exhibit outstanding performance, possess desirable properties, and meet the demands of clinical antiadhesive barriers. 27,28 Hydrogels, 29,30 nanofibers, sponges, 31−33 microparticles, 34,35 and cast films 36 have been used as physical barriers frequently.…”

“…Ideal physical barriers should be biocompatible and biodegradable, have sufficient mechanical strength, easily attach to the wound, and prevent cell penetration without restricting nutrient flow. This can be achieved by using dense poly porous materials with pore sizes smaller than the diameter of a eukaryoyic (10–100 μm). − Due to their dual function as barriers and drug transporters, biomaterials have received considerable attention in preventing PIAs. , Biomaterials engineered with micro- or nanosized structures exhibit outstanding performance, possess desirable properties, and meet the demands of clinical antiadhesive barriers. , Hydrogels, , nanofibers, sponges, − microparticles, , and cast films have been used as physical barriers frequently. Compared to sponges, microparticles, and cast films, nanofibers and hydrogels are widely used due to their ease of forming a two-dimensional membrane and better physical performance.…”