A hybrid learning algorithm consisting of a preprocessor, a k-nearest neighbors regressor, a noise generator, and a particle–wall collision model is introduced for predicting features of turbulent single-phase and particle–liquid flows in a pipe. The hybrid learning algorithm has the ability to learn and predict the behavior of such complex fluid dynamic systems using experimental dynamic databases. Given a small amount of typical training data, the algorithm is able to reliably predict the local liquid and particle velocities as well as the spatial distribution of particle concentration within and without the limits of the range of training data. The algorithm requires an order of magnitude less training data than a typical full set of experimental measurements to give predictions on the same level of accuracy (typically, 20 cf. 100 trajectories for phase velocity distribution and 40 cf. 500 trajectories for phase concentration distribution), thus leading to huge reductions in experimentation and simulation. A feature importance analysis revealed the effects of the different experimental variables on the particle velocity field in a two-phase particulate flow, with particle–liquid density ratio and particle vertical radial position being the most influential and particle concentration the least. The algorithm is amenable to extension by using more complex databanks to address a much more comprehensive range of flow situations.