Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Rognini, Giulio; Petrini, Francesco Maria; Raspopović, Staniša; Valle, Giacomo; Granata, Giuseppe; Strauss, Ivo; Solcà, Marco; Bello-Ruiz, Javier; Herbelin, Bruno; Mange, Robin; D’Anna, Edoardo; Iorio, Riccardo Di; Pino, Giovanni Di; Andreu, David; Guiraud, David; Stieglitz, Thomas; Rossini, Paolo Maria; Serino, Andrea; Micera, Silvestro; Blanke, Olaf

doi:10.1136/jnnp-2018-318570

Cited by 120 publications

(120 citation statements)

References 8 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…This perception causes a mismatching of spatial dimensions and posture of the phantom limb. Thus, we quantified abnormal phantom limb perceptions and evaluated the hypothesis that biomimetic encodings reduced telescoping effect after a VET session (Rognini et al, 2018) ( Figure 4A). The subject reported her phantom arm length (10 repetitions) before and after each session of VET.…”

Section: Distorted Phantom Limb Perception Is Decreased Using Frequenmentioning

confidence: 99%

“…Implantable peripheral nerve interfaces can be reliably used to provide sensory feedback to upper limb amputees (Graczyk et al, 2016;Horch et al, 2011;Ortiz-Catalan et al, 2014;Raspopovic et al, 2014Raspopovic et al, , 2017Tan et al, 2014Tan et al, , 2015. This approach can improve hand prosthesis movement control (Tan et al, 2014(Tan et al, , 2015, is usable and stable over long periods (Ortiz-Catalan et al, 2014;Tan et al, 2015), and fosters embodiment of the prosthesis by the subjects (Rognini et al, 2018;Schiefer et al, 2016). Previous works also showed that different encoding strategies could be used to successfully restore sensory feedback (Graczyk et al, 2016;Horch et al, 2011;Tan et al, 2014, Wendelken et al, 2017.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Valle

Mazzoni

Iberite

et al. 2018

Neuron

Self Cite

287

323

View full text Add to dashboard Cite

show abstract

Section: Distorted Phantom Limb Perception Is Decreased Using Frequenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Valle

Mazzoni

Iberite

et al. 2018

Neuron

Self Cite

287

323

View full text Add to dashboard Cite

show abstract

“…Therefore, it is possible that interference between feedback from natural somatosensory pathways (hand touching the joystick, proprioception) and S1 ICMS feedback made interpretation more difficult for monkey M. This indicates that further studies are necessary to determine, among other things, the best target in S1 for delivering ICMS that encodes tactile signals for future clinical neuroprosthesis. While delivering sensory feedback to an ethologically meaningful cortical area is likely important for the subject to assimilate any limb prosthesis as a natural appendage 35–37 , the use of different somatosensory regions in the cortex may facilitate the sensory-motor integration and tactile acuity. Therefore, we suggest that it may be necessary to deliver artificial sensory feedback to multiple cortical regions simultaneously to achieve the best performance of such limb prostheses.…”

Section: Discussionmentioning

confidence: 99%

Creating a neuroprosthesis for active tactile exploration of textures

O’Doherty

Shokur

Medina

et al. 2019

Preprint

View full text Add to dashboard Cite

39Intracortical microstimulation (ICMS) of the primary somatosensory cortex (S1) can 40 produce percepts that mimic somatic sensation and thus has potential as an approach to 41 sensorize prosthetic limbs. However, it is not known whether ICMS could recreate active texture 42 exploration-the ability to infer information about object texture by using one's fingertips to scan 43 a surface. Here we show that ICMS of S1 can convey information about the spatial frequencies 44 of invisible virtual gratings through a process of active tactile exploration. Two rhesus monkeys 45 scanned pairs of visually identical screen objects with the fingertip of a hand avatar, controlled 46 via a joystick and later via a brain-machine interface, to find the one with denser virtual gratings. 47The gratings consisted of evenly spaced ridges that were signaled through ICMS pulses 48 generated when the avatar's fingertip crossed each ridge. The monkeys learned to interpret 49 these ICMS patterns evoked by the interplay of their voluntary movements and the virtual 50 textures of each object. Discrimination accuracy across a range of grating densities followed 51Weber's law of just-noticeable differences (JND), a finding that matches normal cutaneous 52 sensation. Moreover, one monkey developed an active scanning strategy where avatar velocity 53 was integrated with the ICMS pulses to interpret the texture information. We propose that this 54 approach could equip upper-limb neuroprostheses with direct access to texture features 55 acquired during active exploration of natural objects. 57Sensory neuroprostheses offer the promise of restoring perceptual function to people 59 with impaired sensation 1,2 . In such devices, diminished sensory modalities (e.g., hearing 3 , 60 vision 4,5 , or cutaneous touch 6-8 ) are reenacted through streams of artificial input to the nervous 61 system, typically using electrical stimulation of nerve fibers in the periphery or neurons in the 62 central nervous system. Restored cutaneous touch, in particular, would be of great benefit for 63 the users of upper-limb prostheses, who place a high priority on the ability to perform functions 64 without the necessity to constantly engage visual attention 9 . This could be achieved through the 65 addition of artificial somatosensory channels to the prosthetic device 1 . Such an approach would 66 endow persons suffering from limb loss 10-12 , paralysis 1,13 or somatosensory deficits with the 67 ability to perform active tactile exploration of their physical environment and aid in dexterous 68 object manipulation [14][15][16][17] . 69Previously we demonstrated that motor and sensory functions could be simultaneously 70 enacted though a bidirectional neuroprosthetic system, called a brain-machine-brain interface 71 (BMBI) 18 . In that demonstration, the active exploration enabled by our BMBI-driven 72 neuroprosthesis used a limited and fixed set of ICMS temporal patterns to generate artificial 73 sensory inputs that mimicked the sense of flutter-vibration. However, it r...

show abstract

“…A recent study demonstrated that amputees with prosthetics can be convinced of feeling in their lost limbs if tactile methods are used [7]. …”

Section: Seeing Is Believingmentioning

confidence: 99%

Taking Virtual Reality out of the Game and Into Healthcare

Martin¹,

Lake²

2019

BioTechniques

View full text Add to dashboard Cite

Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Cited by 120 publications

References 8 publications

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Creating a neuroprosthesis for active tactile exploration of textures

Taking Virtual Reality out of the Game and Into Healthcare

Contact Info

Product

Resources

About