Multisensory environmental sensitivity in patients with chronic tinnitus

Danioth, Laura; Brotschi, Gladys; Friedrich, Hergen; Caversaccio, Marco; Negoiaș, Simona

doi:10.1016/j.jpsychores.2020.110155

Cited by 7 publications

(16 citation statements)

References 52 publications

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“…The association between tinnitus and anxiety has been investigated in many previous studies and has been well reviewed [10][11][12][13][14][15][16][17]. However, no information is available on the direction and causality between the two ends of the link [14,16,[46][47][48], although many studies have…”

Section: Discussionmentioning

confidence: 99%

COVID-19 associated anxiety enhances tinnitus

et al. 2021

PLoS ONE

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To investigate if the anxiety associated with coronavirus disease 2019 (COVID-19) is a promoting factor to tinnitus. A retrospective research design collected from 188 tinnitus patients, was used to compare the clinical characteristics of tinnitus between the patients in 2020 under pandemic pressure and those from the matching period in 2019. While anxiety was quantified using the Zung’s Self-rating Anxiety Scale (SAS), tinnitus severity was evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and the test of tinnitus loudness (TL). The assessments were repeated after the sound therapy plus educational counselling (STEC) for 38 patients in 2020 and 58 patients in 2019 and compared with EC alone therapy for 42 patients in 2020 and 17 patients in 2019. A large increase in anxiety was evident in 2020 in both case rate and SAS. The treatment of both methods was less effective in 2020. SAS, THI and TL were all deteriorated after the EC alone treatment in 2020, while an improvement was seen in 2019. This suggests that EC alone could not counteract the stress by COVID-19 at all, and the stress, if not managed well, can significantly increase the severity of tinnitus and associated anxiety. By using the EC subgroup in virtual control, we conclude that anxiety can serve as a promoting factor to tinnitus. We believe that this is the first study report that confirm the causative/promotive role of anxiety on tinnitus during COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

COVID-19 associated anxiety enhances tinnitus

et al. 2021

PLoS ONE

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“…The association between tinnitus and anxiety has been investigated in many previous studies and has been well reviewed (Durai et al, 2016; Malouff et al, 2011; Mazurek et al, 2019; Pattyn et al, 2016; Wallhausser-Franke et al, 2012; Ziai et al, 2017; Zirke et al, 2013). However, no information is available on the direction and causality between the two ends of the link (Danioth et al, 2020; Lugo et al, 2020; Mazurek et al, 2019; Park et al, 2019b; Wallhausser-Franke et al, 2012), although many studies have implied that psychological states, such as those related to common stressors, influence perception of, or coping with tinnitus (Lazarus, 1993; Lazarus, 2000). In this regard, two related systems are involved in tinnitus: (1) the brain regions along the hypothalamic–pituitary– adrenal axis (see reviews (Mazurek et al, 2019; Ziai et al, 2017)), which is the main neuroendocrine system involved in stress response, and (2) the limbic system including the hippocampus and amygdala, which regulates the perception of tinnitus and the adaptation (thereby, the ability to cope with stress) (Chen et al, 2017; Kapolowicz et al, 2019; Leaver et al, 2016; Lockwood et al, 1998; Raghavan et al, 2016; Zhang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…The COVID-19 pandemic provides a good opportunity to investigate whether stress or anxiety could enhance tinnitus as a causative or promotive factor, by clearing some clouds. For example, in many of the previous studies, the effect of anxiety on tinnitus were evaluated in a special population, such as those in veterans (Hu et al, 2015), in elderly (Danioth et al, 2020), in those with headache (Lugo et al, 2020), and those with sleeping disorders (Xu et al, 2016a). In other extreme, the link was investigated in cross-sectional studies in which the anxiety cases of different causes was included (Park et al, 2019a).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 associated anxiety enhances tinnitus

Xia

Wang

Dong

et al. 2020

Preprint

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Background We investigated how the anxiety associated with COVID 19 impacts the severity of tinnitus and the outcomes of tinnitus therapy. Methods and Findings A retrospective research design was used to compare the clinical characteristics of tinnitus between patients from March to April 2020 under pandemic pressure and those from the matching period in 2019. Tinnitus severity was evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and the minimum masking level (MML) measure while anxiety was quantified using the Zung Self-rating Anxiety Scale (SAS). The assessments were repeated after a 2-month interval, in which sound therapy was applied to a subgroup of patients. In all, 94 and 70 cases were reported in the 2020 and 2019 groups, respectively. The effects of the pandemic on emotional status were evident from a higher incidence of anxiety and much higher SAS scores in the 2020 group. There was also an increase in the THI scores in the 2020 group, but the between-year difference was smaller than that of the SAS score. Moreover, there was no between-year difference in MML or the treatment effect, as measured via both THI and MML. Furthermore, the reduction in SAS score in the second assessment was significantly smaller in the 2020 group. However, a positive correlation between the initial SAS score and the improvement was seen within the 2020 group. Conclusions Anxiety increased greatly in tinnitus subjects due to the COVID 19 pandemic. However, this was not associated with an increase in tinnitus severity in 2020. Instead, there was no between-year difference in the THI score or MML or in the improvement of either measure after treatment. The smaller improvement in SAS score and the positive correlation with the initial SAS score in the 2020 group suggests that the SAS score change in this group might largely be due to the natural relief of pressure as the pandemic decelerated in China. Therefore, the anxiety change induced by the COVID 19 pandemic is not likely to have a strong impact on tinnitus.

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“…The association between tinnitus and anxiety has been investigated in many previous studies and has been well reviewed [9][10][11][12][13][14][15]. However, no information is available on the direction and causality between the two ends of the link [13,15,[39][40][41], although many studies have implied that psychological states, such as those related to common stressors, in uence perception of, or coping with tinnitus [42,43]. In this regard, two related systems are involved in tinnitus: (1) the brain regions along the hypothalamicpituitary-adrenal axis (see reviews [9,13]), which is the main neuroendocrine system involved in stress response, and (2) the limbic system including the hippocampus and amygdala, which regulates the perception of tinnitus and the adaptation (thereby, the ability to cope with stress) [44][45][46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19 Associated Anxiety Enhances Tinnitus: A Case Control Study

Chen

Xia

et al. 2020

Preprint

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Background: The directional nature of the link between anxiety and tinnitus has not been verified. COVID-19 has added stress to involved residents and provided a good opportunity to discover if anxiety/stress plays a causative/promotive role to tinnitus. Methods: A retrospective research design was used to compare the tinnitus clinics between the patients in 2020 under COVID-19 and those from the matching period in 2019. While anxiety was quantified using the Zung’s Self-rating Anxiety Scale (SAS), tinnitus severity was evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and the test of minimum masking level (MML). The assessments were repeated after two months of therapy with sound therapy + educational counselling (STEC) or EC alone. Results: A large increase in anxiety was evident in 2020 in both case rate and SAS. The treatment of both methods was less effective in 2020. SAS, THI and MML were all deteriorated after the EC alone treatment in 2020, while an improvement was seen in 2019. Discussion: The differences between years and between treatment methods suggest that EC alone could not counteract the stress by COVID-19 at all, and the stress, if not managed well, can significantly increase the severity of tinnitus and associated anxiety.Conclusions: By using the EC subgroup in virtual control, we conclude that anxiety can serve as a promoting factor to tinnitus. We believe that this is the first study report that confirm the causative/promotive role of anxiety on tinnitus

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Multisensory environmental sensitivity in patients with chronic tinnitus

Cited by 7 publications

References 52 publications

COVID-19 associated anxiety enhances tinnitus

COVID-19 associated anxiety enhances tinnitus

COVID-19 associated anxiety enhances tinnitus

COVID-19 Associated Anxiety Enhances Tinnitus: A Case Control Study

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