Multisensory Integration in Migraine: Recent Developments

O’Hare, Louise

doi:10.1163/22134808-00002570

Cited by 7 publications

(4 citation statements)

References 73 publications

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“…Migraine is a common neurological disorder characterised by a unilateral, pulsating headache with moderate to severe pain. Migraines are accompanied by changes in sensory processing, including heightened sensitivity to light (photophobia) and sound (phonophobia), and altered multisensory processing (for reviews see, O'Hare, 2017, andSchwedt, 2013).…”

Section: Migraine and Headachesmentioning

confidence: 99%

What you see is what you hear: Twenty years of research using the Sound-Induced Flash Illusion

Hirst¹,

McGovern²,

Setti³

et al. 2020

Preprint

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In the Sound-Induced Flash Illusion (SIFI) sound dramatically alters visual perception, as presenting a single flash with two beeps results in the perception of two flashes. In this timely review, we synthesise 20 years of research using the SIFI, from over 100 studies. We discuss the neural and computational principles governing this illusion and examine the influence of perceptual experience, development, ageing and clinical conditions. Convergent findings show that the SIFI results from optimal integration and probabilistic inference and directly probes crossmodal interactions in the temporal domain. Its neural basis lies in early modulation of visual cortex by auditory and multisensory regions. The SIFI shows increasingly strong potential as an efficient tool for measuring multisensory processing. Greater harmonisation across studies is now required to maximise this potential. We therefore propose considerations for researchers relating to choice of stimulus parameters and signpost directions for future research.

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Section: Migraine and Headachesmentioning

confidence: 99%

What you see is what you hear: Twenty years of research using the Sound-Induced Flash Illusion

Hirst¹,

McGovern²,

Setti³

et al. 2020

Preprint

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“…This is indeed a surprising and unexpected result. It is generally accepted in the literature that altered multisensory processing is a characteristic feature of migraine (25)(26)(27)(28)(29), but, to our knowledge, no study before has reported enhanced multisensory performance in migraine patients. Furthermore, improved associative learning performance was accompanied by significantly shorter reaction times, which is exactly what one expects in the context of multisensory facilitation (30).…”

Section: Discussionmentioning

confidence: 85%

Enhanced audiovisual associative pair learning in migraine without aura in adult patients: An unexpected finding

Tót,

Braunitzer,

Harcsa-Pintér

et al. 2024

Cephalalgia

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Background Altered sensory processing in migraine has been demonstrated by several studies in unimodal, and especially visual, tasks. While there is some limited evidence hinting at potential alterations in multisensory processing among migraine sufferers, this aspect remains relatively unexplored. This study investigated the interictal cognitive performance of migraine patients without aura compared to matched controls, focusing on associative learning, recall, and transfer abilities through the Sound-Face Test, an audiovisual test based on the principles of the Rutgers Acquired Equivalence Test. Materials and Methods The performance of 42 volunteering migraine patients was compared to the data of 42 matched controls, selected from a database of healthy volunteers who had taken the test earlier. The study aimed to compare the groups’ performance in learning, recall, and the ability to transfer learned associations. Results Migraine patients demonstrated significantly superior associative learning as compared to controls, requiring fewer trials, and making fewer errors during the acquisition phase. However, no significant differences were observed in retrieval error ratios, generalization error ratios, or reaction times between migraine patients and controls in later stages of the test. Conclusion The results of our study support those of previous investigations, which concluded that multisensory processing exhibits a unique pattern in migraine. The specific finding that associative audiovisual pair learning is more effective in adult migraine patients than in matched controls is unexpected. If the phenomenon is not an artifact, it may be assumed to be a combined result of the hypersensitivity present in migraine and the sensory threshold-lowering effect of multisensory integration.

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“…However, studies on cyclic changes of multisensory integration across different phases are still lacking. The investigation into the mechanisms of how multisensory integration changes across migraine phases may provide new insight into the generation of migraine attacks [10,54].…”

Section: Multisensory Integrationmentioning

confidence: 99%

Cycling multisensory changes in migraine: more than a headache

Peng

May

Basedau

2022

Current Opinion in Neurology

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Purpose of reviewResearch on migraine usually focuses on the headache; however, accumulating evidence suggests that migraine not only changes the somatosensory system for nociception (pain), but also the other modalities of perception, such as visual, auditory or tactile sense. More importantly, the multisensory changes exist beyond the headache (ictal) phase of migraine and show cyclic changes, suggesting a central generator driving the multiple sensory changes across different migraine phases. This review summarizes the latest studies that explored the cyclic sensory changes of migraine.Recent findingsConsiderable evidence from recent neurophysiological and functional imaging studies suggests that alterations in brain activation start at least 48 h before the migraine headache and outlast the pain itself for 24 h. Several sensory modalities are involved with cyclic changes in sensitivity that peak during the ictal phase.SummaryIn many ways, migraine represents more than just vascular-mediated headaches. Migraine alters the propagation of sensory information long before the headache attack starts.

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Multisensory Integration in Migraine: Recent Developments

Cited by 7 publications

References 73 publications

What you see is what you hear: Twenty years of research using the Sound-Induced Flash Illusion

What you see is what you hear: Twenty years of research using the Sound-Induced Flash Illusion

Enhanced audiovisual associative pair learning in migraine without aura in adult patients: An unexpected finding

Cycling multisensory changes in migraine: more than a headache

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