Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systems

Budinger, Eike; Heil, Peter; Heß, Andreas; Scheich, Henning

doi:10.1016/j.neuroscience.2006.08.035

Cited by 265 publications

(251 citation statements)

References 88 publications

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“…Finally, a visuo-auditory projection arose from an area anterior to the superior temporal sulcus (STS) towards the auditory core. The heteromodal connections between the primary somatosensory cortex and the primary auditory cortex were also reported in the gerbils (Budinger et al, 2006). In marmosets, projections from the retroinsular area of the somatosensory cortex to the caudiomedial belt auditory area were also observed (de la Mothe et al, 2006a) in line with a similar observation in the Old World monkey (Smiley et al, 2007).…”

Section: Primary Sensory Areas Receive Non-specific Inputssupporting

confidence: 70%

Multisensory anatomical pathways

2009

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In order to interact with the multisensory world that surrounds us, we must integrate various sources of sensory information (vision, hearing, touch. . .). A fundamental question is thus how the brain integrates the separate elements of an object defined by several sensory components to form a unified percept. The superior colliculus was the main model for studying multisensory integration. At the cortical level, until recently, multisensory integration appeared to be a characteristic attributed to high-level association regions. First, we describe recently observed direct cortico-cortical connections between different sensory cortical areas in the non-human primate and discuss the potential role of these connections. Then, we show that the projections between different sensory and motor cortical areas and the thalamus enabled us to highlight the existence of thalamic nuclei that, by their connections, may represent an alternative pathway for information transfer between different sensory and/or motor cortical areas. The thalamus is in position to allow a faster transfer and even an integration of information across modalities. Finally, we discuss the role of these non-specific connections regarding behavioral evidence in the monkey and recent electrophysiological evidence in the primary cortical sensory areas.

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Section: Primary Sensory Areas Receive Non-specific Inputssupporting

confidence: 70%

Multisensory anatomical pathways

2009

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“…This idea of flexible task-dependent interactions in cortex is much supported by human fMRI results (44,45) and by anatomical evidence. Unlike subcortical auditory stations where processing steps can be explained by convergent and divergent ascending inputs, even primary AC receives Ͼ50% of its inputs from other cortical areas including many nonauditory fields (60). Thus, the essence of cortical auditory processing is the top-down access to and interaction with other cortical functions that do not serve auditory analysis of sounds but rather their conceptualization and interpretation (47).…”

Section: Discussionmentioning

confidence: 99%

Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions

Wetzel

Ohl

Scheich

2008

Proc. Natl. Acad. Sci. U.S.A.

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Hemispheric asymmetries of speech and music processing might arise from more basic specializations of left and right auditory cortex (AC). It is not clear, however, whether such asymmetries are unique to humans, i.e., consequences of speech and music, or whether comparable lateralized AC functions exist in nonhuman animals, as evolutionary precursors. Here, we investigated the cortical lateralization of perception of linearly frequency-modulated (FM) tones in gerbils, a rodent species with human-like lowfrequency hearing. Using a footshock-reinforced shuttle-box avoidance go/no-go procedure in a total of 178 gerbils, we found that (i) the discrimination of direction of continuous FM (rising versus falling sweeps, 250-ms duration) was impaired by right but not left AC lesions; (ii) the discrimination of direction of segmented FM (50-ms segments, 50-ms silent gaps, total duration 250 ms) was impaired by bilateral but not unilateral AC lesions; (iii) the discrimination of gap durations (10 -30 ms) in segmented FM was impaired by left but not right AC lesions. AC lesions before and after training resulted in similar effects. Together, these experiments suggest that right and left AC, even in rodents, use different strategies in analyzing FM stimuli. Thus, the right AC, by using global cues, determines the direction of continuous and segmented FM but cannot discriminate gap durations. The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available.asymmetry ͉ lateralization ͉ rodents

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“…We now know that, not only higher cortex, but also probably most of the primary sensory cortex, is polysensory (Falchier et al, 2002;Rockland and Ojima, 2003;Clavagnier et al, 2004;Budinger et al, 2006;Driver and Noesselt, 2008;Ptito et al, 2008;Collignon et al, 2009). Ghazanfar and Schroeder (2006) conclude that, "The nature of most, possibly all, of the neocortex forces us to abandon the notion that the senses ever operate independently during realworld cognition."…”

Section: Two Binding Systems?mentioning

confidence: 99%