Splines form an elegant bridge between the continuous real world and the discrete computational world. Their tensor-product form lifts many univariate properties effortlessly to the surfaces, volumes and beyond. Irregularities, where the tensor-structure breaks down, therefore deserve attention-and provide a rich source of mathematical challenges and insights. This paper reviews and categorizes techniques for splines on meshes with irregularities. Of particular interest are quad-dominant meshes that can have n = 4 valent interior points and T-junctions where quad-strips end. "Generalized" splines can use quad-dominant meshes as control nets both for modeling geometry and to support engineering analysis without additional meshing.