Multislice Computed Tomography Angiography Imaging Diagnosis of Lower Extremity Arteriosclerosis in Patients with Hypertension and Its Correlation with the Level of High-Sensitivity C-Reactive Protein

Huo, Jing; Jiang, Haijun; Zhang, Hong

doi:10.1155/2022/1768208

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…2 Therefore, screening procedures are critical for the early detection of PAD and the prevention of complications, particularly limb amputation. 2,3 Globally, an estimated 200 million people suffer from occlusive arteriosclerosis, which can be life-threatening. 3 The estimated prevalence of PAD in the Asian continent is 6-10%.…”

Section: Introductionmentioning

confidence: 99%

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Anatomical Distribution Patterns of Peripheral Arterial Disease According to Patient Characteristics: A Unicentral Cohort Study

Alghanimi¹,

Al-Sharydah²,

Alqutub³

et al. 2023

VHRM

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Peripheral arterial disease (PAD) is a common disease with multiple risk factors and affects patients worldwide. Several international studies have established correlations between anatomical topography/distribution of atherosclerosis and comorbidities in patients with PAD. In this cohort study, we aimed to analyze the patterns of atherosclerosis (site, distribution, and degree) in patients who underwent lower limb computed tomography angiography and arterial angiography by identifying the atherosclerotic plaque(s) that were possibly responsible for thrombi. Additionally, we aimed to determine any relationship between comorbidities and identified patterns. Patients and Methods: Between January 2015 and January 2021, we retrospectively recruited 140 patients at King Fahd Hospital of the University of Saudi Arabia. Data collected included patient characteristics, risk factors, and metabolic disorders, such as hypertension (HTN), diabetes mellitus (DM), dyslipidemia, and chronic kidney disease. Patients with incomplete records or unavailable radiological images were excluded. Results: The infrapopliteal territory was the most common segment that was affected. HTN, DM, and dyslipidemia were found in 81.4%, 77.9%, and 62.9% of patients, respectively. Correlation analyses revealed that DM was the only independent metabolic disorder associated with a PAD distribution pattern in the femoropopliteal segment (p=0.039), thus denoting distal involvement. No significant association was found between PAD distribution and the severity of stenosis. Conclusion: Segmental involvement in PAD varies with the risk factors and metabolic comorbidities present in patients. DM is an independent predictor of the anatomical distribution of PAD. The identification of such an anatomical distribution is paramount for screening procedures, early detection of disease, and prevention of complications, particularly limb amputation.

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Section: Introductionmentioning

confidence: 99%

“…2,3 Globally, an estimated 200 million people suffer from occlusive arteriosclerosis, which can be life-threatening. 3 The estimated prevalence of PAD in the Asian continent is 6-10%. 4,5 The prevalence of PAD also increases with age (20% at 40 years and 29% in those aged over 50 years).…”

Section: Introductionmentioning

confidence: 99%

Anatomical Distribution Patterns of Peripheral Arterial Disease According to Patient Characteristics: A Unicentral Cohort Study

Alghanimi¹,

Al-Sharydah²,

Alqutub³

et al. 2023

VHRM

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“…Several cohort studies have reported that an elevated hs-CRP level is independently associated with an increased incidence of major cerebrovascular and cardiovascular outcomes (34,35). Similarly, many recent studies have shown that the hs-CRP level is positively correlated with CV risk in various clinical settings (36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 98%

Association of mercury exposure with the serum high-sensitivity C-reactive protein level in Korean adults

Kim

Park

2023

Front. Public Health

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Although there is evidence that mercury (Hg) exposure may be a potential risk factor for cardiovascular disease (CVD), few nationwide epidemiological researches have analyzed the association between blood Hg concentration and serum high-sensitivity C-reactive protein (hs-CRP) level as a biomarker of CVD. The present population-based national study was performed with data from the 2016–2017 National Health and Nutrition Examination Survey. In the total sample of 3,773 adults aged ≥20 years, the serum hs-CRP concentrations were 1.03 mg/L among participants in the lowest quartile of blood Hg level and 1.18 mg/L among those in highest quartile. The trend for the prevalence of a risky (>1.0 mg/L) hs-CRP level (moderate risk and high risk) was significantly related to an increased quartile blood Hg concentration. After adjustment for confounders, participants with the highest quartiles of blood Hg had increased odds of a risky (>1.0 mg/L) hs-CRP level (adjusted odds ratio = 1.34; 95% confidence interval, 1.02–1.77) compared with those with the lowest quartile of blood Hg. These findings demonstrate that a high blood Hg level increases the concentration of serum hs-CRP, a sensitive marker of chronic low-grade inflammation, and imply that the increased body burden associated with high blood Hg is a potential risk factor in the development of many inflammatory diseases, including CVD.

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“…Also, hsCRP was found to be higher in Wegener’s granulomatosis cases that are in relapse, and serial CRP measurement fills the urgent need for an objective index of the activity of this disease [ 668 , 669 , 670 , 671 ]. Apart from Kawasaki disease, in which data are contrasted, some authors believe that arteriosclerosis is an autoimmune condition; hsCRP has been correlated with disease severity, and a study found that SNPs affect arterial pulse wave velocity in healthy people [ 672 , 673 ]. Studies on paroxysmal nocturnal hemoglobinuria and CRP are limited, and notably elevated CRP values can be seen in some case reports—possibly in relapses [ 674 , 675 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Multislice Computed Tomography Angiography Imaging Diagnosis of Lower Extremity Arteriosclerosis in Patients with Hypertension and Its Correlation with the Level of High-Sensitivity C-Reactive Protein

Cited by 5 publications

References 23 publications

Anatomical Distribution Patterns of Peripheral Arterial Disease According to Patient Characteristics: A Unicentral Cohort Study

Anatomical Distribution Patterns of Peripheral Arterial Disease According to Patient Characteristics: A Unicentral Cohort Study

Association of mercury exposure with the serum high-sensitivity C-reactive protein level in Korean adults

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

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