This research work presents the development of an Ultra-Wideband (UWB) microstrip patch antenna (MPA) with the specific purpose of tissue characterization. The antenna was carefully designed and simulated to operate within a frequency range of 4.8 to 6.9 GHz, optimized for its intended application. To ensure the best performance, a series of simulations and comparisons were conducted using CST Microwave Studio. Various antenna shapes were tested and evaluated to determine the most effective design. The results of these simulations were highly promising, as they revealed a simulated return loss (𝑆 11 ) of -33dB. This indicates excellent performance and demonstrates the suitability and acceptability of the proposed antenna for medical imaging such as breast imaging, tumor detection, or monitoring physiological changes.