Multispecies probiotic affects fecal short-chain fatty acids in postmenopausal women with obesity: A post hoc analysis of a randomized, double-blind, placebo-controlled study

Łoniewski, Igor; Szulińska, Monika; Kaczmarczyk, Mariusz; Podsiadło, Konrad; Styburski, Daniel; Skonieczna-Żydecka, Karolina; Bogdański, Paweł

doi:10.1016/j.nut.2023.112109

Cited by 3 publications

(4 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

“…In a randomized, double-blind, placebo-controlled study assessing the impact of the probiotic intervention on fecal SCFAs, a multi-strain probiotic formula was administered to 56 postmenopausal obese women [415]. The study revealed a positive effect on their cardiometabolic health, with the higher probiotic dose group showing elevated levels of fecal SCFAs [415]. Another recent study investigated the impact of a low-carbohydrate diet compared to a habitual diet on fecal SCFA levels and serum inflammatory markers in obese women undergoing an energy-restricted diet [416].…”

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Short-chain Fatty Acids and Human Health: from Metabolic Pathways to Current Therapeutic Implication

Facchin,

Bertin,

Bonazzi

et al. 2024

Preprint

View full text Add to dashboard Cite

The gastrointestinal tract is colonized by trillions of different microorganisms, named the gut microbiota, which is key to degrade undigested food such as dietary fibers. The fermentation of these food components leads to the production of short-chain fatty acids (SCFA) acetate, propionate, and butyrate, which exploit several beneficial roles for the host’s health. Their production and absorption happen in different ways in the human intestine and depend on the type of dietary fiber reaching the gut and the microorganisms involved in the fermentation. The supplementation of SCFAs, mostly butyrate, in treating gastrointestinal, metabolic, cardiovascular, and gut-brain-related diseases has been reported in the medical literature. This review aims to give an overview of the production and absorption dynamics of acetate, propionate, and butyrate in the human gut, with a final focus on the role played by these SCFAs on gastrointestinal and metabolic health and the present therapeutic implications.

show abstract

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

Short-chain Fatty Acids and Human Health: from Metabolic Pathways to Current Therapeutic Implication

Facchin,

Bertin,

Bonazzi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

“…In a randomized, double-blind, placebo-controlled study assessing the impact of the probiotic intervention on fecal SCFAs, a multi-strain probiotic formula was administered to 56 postmenopausal obese women [399]. The study revealed a positive effect on their cardiometabolic health, with the higher probiotic dose group showing elevated levels of fecal SCFAs [399]. Another recent study investigated the impact of a low-carbohydrate diet compared to a habitual diet on fecal SCFAs levels and serum inflammatory markers in obese women undergoing an energy-restricted diet [400].…”

Section: Prebiotic and Probiotic Applicationsmentioning

confidence: 99%

Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

Facchin,

Bertin,

Bonazzi

et al. 2024

Life

View full text Add to dashboard Cite

The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such as dietary fibers. Through the fermentation of these food components, short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are produced, offering numerous health benefits to the host. The production and absorption of these SCFAs occur through various mechanisms within the human intestine, contingent upon the types of dietary fibers reaching the gut and the specific microorganisms engaged in fermentation. Medical literature extensively documents the supplementation of SCFAs, particularly butyrate, in the treatment of gastrointestinal, metabolic, cardiovascular, and gut-brain-related disorders. This review seeks to provide an overview of the dynamics involved in the production and absorption of acetate, propionate, and butyrate within the human gut. Additionally, it will focus on the pivotal roles these SCFAs play in promoting gastrointestinal and metabolic health, as well as their current therapeutic implications.

show abstract

Utilizing pigs as a model for studying intestinal barrier function

Pieszka,

Szczepanik,

Łoniewski

2024

Annals of Animal Science

View full text Add to dashboard Cite

Intestinal permeability has been extensively studied, particularly in gastrointestinal diseases such as inflammatory bowel disease, food allergy, visceral disease, celiac disease, and Crohn’s disease. These studies have established that changes in intestinal permeability contribute to the pathogenesis of many gastrointestinal and systemic diseases. While numerous works in the 20th century focused on this topic, it remains relevant for several reasons. Despite the development of new research techniques, it is still unclear whether changes in intestinal permeability are the primary mechanism initiating the disease process or if they occur secondary to an ongoing chronic inflammatory process. Investigating the possibility of stabilizing the intestinal barrier, thereby reducing its permeability preemptively to prevent damage and after the damage has occurred, may offer new therapeutic approaches. Increased intestinal permeability is believed to lead to reduced nutrient absorption, resulting in decreased immunity and production of digestive enzymes.

show abstract

Multispecies probiotic affects fecal short-chain fatty acids in postmenopausal women with obesity: A post hoc analysis of a randomized, double-blind, placebo-controlled study

Cited by 3 publications

References 82 publications

Short-chain Fatty Acids and Human Health: from Metabolic Pathways to Current Therapeutic Implication

Short-chain Fatty Acids and Human Health: from Metabolic Pathways to Current Therapeutic Implication

Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

Utilizing pigs as a model for studying intestinal barrier function

Contact Info

Product

Resources

About