Multispectral breast imaging using a ten‐wavelength,  source/detector channels silicon photodiode‐based diffuse optical tomography system

Li, Chang Qing; Zhao, Hongzhi; Anderson, Bonnie Brinton; Jiang, Huabei

doi:10.1118/1.2171508

Cited by 48 publications

(29 citation statements)

References 23 publications

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“…In the simulations, we assumed that the tissue sample had a homogenous background consisting of widely distributed components such as water, lipid and hemoglobin. The changes of the molecular components characteristic of the diseased conditions were treated as perturbations and solved later [28]. The background optical properties were calculated based on the absorption spectra in Fig.…”

Section: Non-uniform Response Along Depth Dimension Pa Measurementmentioning

confidence: 99%

Characterizing intestinal inflammation and fibrosis in Crohn’s disease by photoacoustic imaging: feasibility study

Lei

Johnson

Liu

et al. 2016

Biomed. Opt. Express

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Abstract:The pathology of Crohn's disease (CD) is characterized by obstructing intestinal strictures because of inflammation (with high levels of hemoglobin), fibrosis (high levels of collagen), or a combination of both. The accurate characterization of the strictures is critical for the management of CD. This study examines the feasibility of characterizing intestinal strictures by Photoacoustic imaging (PAI) without extrapolation from superficial biopsies. Ex vivo normal rat colon tissue, inflammatory and fibrotic intestinal strictures in rat trinitrobenzene sulfonic acid (TNBS) model were first differentiated by a PA-US parallel imaging system. Surgically removed human intestinal stricture specimens were afterwards imaged by a multiwavelength acoustic resolution PA microscope (ARPAM). The experiment results suggest that PAI is a potential tool for the diagnosis of the diseased conditions in intestinal strictures. 2166-2185 (1990). 14. R. Richards-Kortum and E. Sevick-Muraca, "Quantitative optical spectroscopy for tissue diagnosis," Annu. Rev.Phys. Chem. 47(1), 555-606 (1996). 15. H. Messmann, E. Endlicher, G. Freunek, P. Rümmele, J. Schölmerich, and R. Knüchel, "Fluorescence endoscopy for the detection of low and high grade dysplasia in ulcerative colitis using systemic or local 5-aminolaevulinic acid sensitisation," Gut 52 (

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Section: Non-uniform Response Along Depth Dimension Pa Measurementmentioning

confidence: 99%

Characterizing intestinal inflammation and fibrosis in Crohn’s disease by photoacoustic imaging: feasibility study

Lei

Johnson

Liu

et al. 2016

Biomed. Opt. Express

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“…Various research groups have reported success in characterizing breast tumor properties for diagnosis [1][2][3][4][5][6][7][8][9][10][11][12][13][14], as well as treatment monitoring purposes [5,15,16]. A common characteristic of the vast majority of published optical studies is their focus on static, single-shot images.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Functional and Mechanical Response of Breast Tissue to Compression

Carp¹,

Selb²,

Fang³

et al. 2008

Biomedical Optics

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Physiological tissue dynamics following breast compression offer new contrast mechanisms for evaluating breast health and disease with near infrared spectroscopy. We monitored the total hemoglobin concentration and hemoglobin oxygen saturation in 28 healthy female volunteers subject to repeated fractional mammographic compression. The compression induces a reduction in blood flow, in turn causing a reduction in hemoglobin oxygen saturation. At the same time, a two phase tissue viscoelastic relaxation results in a reduction and redistribution of pressure within the tissue and correspondingly modulates the tissue total hemoglobin concentration and oxygen saturation. We observed a strong correlation between the relaxing pressure and changes in the total hemoglobin concentration bearing evidence of the involvement of different vascular compartments. Consequently, we have developed a model that enables us to disentangle these effects and obtain robust estimates of the tissue oxygen consumption and blood flow. We obtain estimates of 1.9±1.3 µmol/100mL/min for OC and 2.8±1.7 mL/100mL/min for blood flow, consistent with other published values.

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“…CW measurements at multiple wavelengths in the near infrared (NIR) wavelength range were used to reconstruct different absorption chromophores in tissues. [10][11][12][13][14] Most DOT breast imaging systems used fibers to deliver lasers to breast surface and collected the diffused light on the breast surface, in which the measurement number was determined by the optode pairings. 11,[15][16][17][18][19][20][21][22] To increase the number of measurement data, Culver et al reported a charge coupled device (CCD) camera based DOT imaging system.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

Self Cite

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Abstract. Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as hemoglobin, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer imaging. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at the wavelength of 650 nm and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements and width of measurement patch, have been investigated. Our results indicate that an air-cooling EMCCD camera is good enough for the transmission mode DOT imaging. We have also found that measurements at six angular projections are sufficient for DOT to reconstruct the optical targets with 2 and 4 times absorption contrast when the CT guidance is applied. Finally, we have described our future research plan on integration of a multispectral DOT imaging system into a breast CT scanner.

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Multispectral breast imaging using a ten‐wavelength, source/detector channels silicon photodiode‐based diffuse optical tomography system

Cited by 48 publications

References 23 publications

Characterizing intestinal inflammation and fibrosis in Crohn’s disease by photoacoustic imaging: feasibility study

Characterizing intestinal inflammation and fibrosis in Crohn’s disease by photoacoustic imaging: feasibility study

Dynamic Functional and Mechanical Response of Breast Tissue to Compression

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

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