Multispectral Optoacoustic Tomography in Crohn’s Disease: Noninvasive Imaging of Disease Activity

Waldner, Maximilian J.; Knieling, Ferdinand; Egger, C.; Morscher, Stefan; Claussen, Jing; Vetter, Marcel; Kielisch, C; Fischer, Sarah; Pfeifer, Lukas; Hagel, Alexander; Goertz, Ruediger S.; Wildner, Dane; Atreya, Raja; Strobel, D

doi:10.1053/j.gastro.2016.05.047

Cited by 69 publications

(66 citation statements)

References 5 publications

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Section: Resultsmentioning

confidence: 99%

“…The MSOT apparatus for use in human subjects consists of a handheld probe similar to bedside ultrasound (10, 13, 18). Improvements in depth of tissue penetration of optoacoustic imaging beyond 1 cm have been demonstrated in humans using the clinical MSOT system, Acuity, with up to 5 cm depth achieved (10, 18). Therefore, MSOT could be used to provide non-invasive screening for IBD in patients at high risk for developing the disease owing to factors such as family history and ethnicity, thereby enabling earlier detection of disease and commencement of therapy to prevent progression.…”

Section: Resultsmentioning

confidence: 99%

“…To date, MSOT has demonstrated resolution at 78.9 μm (5,6). Furthermore, it can detect changes in tissue architecture and the presence of oxygenated and deoxygenated hemoglobin (5–10) permitting evaluation of changes in structure and vascularity, common in IBD. Recently, MSOT instrumentation has evolved and includes the potential for combination of detecting both optoacoustic and ultrasound signals which increases its radiological capabilities.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography

et al. 2016

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Currently, several non-invasive modalities, including MRI and PET, are being investigated to identify early intestinal inflammation, longitudinally monitor disease status, or detect dysplastic changes in patients with inflammatory bowel disease (IBD). Here, we assess the applicability and utility of multispectral optoacoustic tomography (MSOT) in evaluating the presence and severity of colitis. Mice with bacterial colitis demonstrated a temporally associated increase in mesenteric and colonic vascularity with an increase in mean signal intensity of oxygenated hemoglobin (p=0.004) by MSOT two days after inoculation. These findings were significantly more prominent 7 days after inoculation, with increased mean signal intensity of oxygenated hemoglobin (p=0.0002) and the development of punctate vascular lesions on the colonic surface, which corresponded to changes observed on colonoscopy as well as histology. With improvements in depth of tissue penetration, MSOT may hold potential as a sensitive, accurate, non-invasive imaging tool in evaluation of patients with IBD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography

et al. 2016

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“…Another, more sensitive method for the detection of inflammation in the small intestine is capsule endoscopy [20]. Possibly, multispectral optoacoustic tomography could improve the sensitivity for non-invasive detection of inflammation in the gut in the future [21, 22]. Direct drug-monitoring could also become important in the future [23].…”

Section: Therapy In CD – Goals and Controlsmentioning

confidence: 99%

Treatment Perspectives in Crohn’s Disease

Vetter¹

2018

Digestion

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Background: Crohn’s disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. The pathophysiological understanding of this disease is limited and no curative therapy is available so far. Therefore, most patients require long-lasting or even life-long immunosuppressive therapies for the suppression of symptoms to improve quality of life and reduction of long-term risks. However, in a relevant subgroup of patients, these therapeutic goals cannot be sufficiently attained. Summary: Clinically established therapies in active CD comprise corticosteroids and immunosuppressants such as azathioprine. After the introduction of anti-TNFα (Tumor necrosis factor alpha) antibodies, other biologicals (e.g., vedolizumab and ustekinumab) have also been approved. New drugs in the pipeline like filgotinib, upadacitinib, risankizumab or rifaximin could improve the therapy of CD in the near future. Thus, an individualized therapy management, based on optimal selection of therapeutic agents will become more important. Additionally, the local application of mesenchymal stem cells might be helpful in the management of fistulas. Key Messages: The targeted biological therapeutic agents (anti-TNFα antibodies, vedolizumab, ustekinumab) are well established for therapy in CD. There are several new substances in the pipeline with promising results in phase II trials (filgotinib, rifaximin, risankizumab, upadacitinib). The upcoming extension of the therapeutic arsenal will require methods for an optimized selection of substances, thus enabling a more individualized therapy.

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“…This novel optical imaging modality has been demonstrated to have improved resolution and optical imaging accuracy combined with excellent spatial resolution and deep tissue penetration depth [89,90]. Recent applications have revealed its utility for in vivo imaging in cancer, cardiovascular disease, neurology [91], nephrotoxicity applications [92], as well as in the clinic for the non-invasive imaging of disease activity in Crohn's disease [93] and the detection of oesophageal varices [94]. MSOT imaging has also been previously used to measure kidney function in adriamycin-induced nephropathy mice model by measuring IRDye 800CW clearance through kidneys in combination with standard biochemical and histological indicators of kidney damage [92].…”

Section: Multispectral Optoacoustic Tomography (Msot)mentioning

confidence: 99%