Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow

Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease

“…MSOT is further limited by imaging depth and influential factors such as bowel movement and air filling. However, first data on the precision of MSOT for longitudinal assessment of the intestine showed that physiological conditions such as sex and postprandial increased blood flow do not alter the OAI haemoglobin signals [60] . However, imaging depth partially correlates with signal intensities [25] , [60] and might be improved by advanced depth correction algorithms [61] .…”

Ultrasound in Pediatric Inflammatory Bowel Disease—A Review of the State of the Art and Future Perspectives

“…The MSOT signal levels for hemoglobin correlated well with disease phenotype with minimal effort from the patient, and with high accuracy in the detection of remission and active disease [124]. In addition, studies on the precision of MSOT for imaging the human intestine showed resilient data [125], and the option of imaging luminal contrast agents throughout the intestinal tract opens the door to further translational applications and functional assessment of the gastrointestinal tract [126][127][128]. Such approaches might help to delineate complications likes fistulae, which are common manifestations in CD patients [129,130].…”

Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in Late-onset Pompe disease

“…Therefore, less invasive techniques, such as MSOT may hold great potential as a prognostic biomarker for phenotyping LOPD. The capability of MSOT has already been explored in gastroenterology, 34,[54][55][56][57] rheumatology, 58 cardiovascular 59 and cancer medicine 60 or more speci cally in muscle applications 35 such as Duchenne muscular dystrophy 21 and spinal muscular atrophy. 23 In this study, we assume that we were able to depict and quantify the muscle remodeling with localized glycogen accumulation, subsequently leading to bro-fatty replacement and muscle atrophy.…”

“…Imaging was performed by two MSOT-experienced examiners (ALW, RR) at UHE and two MSOTexperienced examiners (SM, JZ) at UMG using at each site a different hybrid MSOT/RUCT (Re ected ultrasound computed tomography) imaging system (MSOT Acuity Echo, iThera Medical GmbH, Munich, Germany). As described before, 21,23,55,[68][69][70][71] a handheld 2D probe (center frequency: 4MHz, eld of view: 40 x 40 mm, 256 transducer elements, spatial resolution: 150 µm) was positioned at 90-degree angle and transparent ultrasound gel was used for coupling. Laser was set to a single wavelength (SWL) starting from 700-1210 nm (700 nm, 730 nm, 760 nm, 800 nm, 850 nm, 910 nm, 930 nm, 950 nm, 980 nm, 1030 nm, 1080 nm, 1100 nm, 1210 nm, Hb and HbO 2 spectrum) with a repetition rate of 25 Hz.…”