Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders

Nam, Judy; Ly, Angelica; Kalloniatis, Michael; Nivison‐Smith, Lisa

doi:10.1038/s41598-022-11070-6

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Even though it is a great tool for assessing AMD progression, some studies showed decreased sensitivity and specificity of drusen change quantification measured by Cirrus Advanced RPE Analysis when compared to a multispectral pattern recognition change analysis or expert graders. The multispectral pattern recognition change analysis is a multimodal approach assessment that includes fundus autofluorescence, infrared 815 nm, and green 532 nm ophthalmoscopy image scanning [103].…”

Section: Oct Evaluation Of Drusenmentioning

confidence: 99%

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers

Iliescu,

Ghita,

Ilie

et al. 2024

Diagnostics

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The imagistic evaluation of non-neovascular age-related macular degeneration (AMD) is crucial for diagnosis, monitoring progression, and guiding management of the disease. Dry AMD, characterized primarily by the presence of drusen and retinal pigment epithelium atrophy, requires detailed visualization of the retinal structure to assess its severity and progression. Several imaging modalities are pivotal in the evaluation of non-neovascular AMD, including optical coherence tomography, fundus autofluorescence, or color fundus photography. In the context of emerging therapies for geographic atrophy, like pegcetacoplan, it is critical to establish the baseline status of the disease, monitor the development and expansion of geographic atrophy, and to evaluate the retina’s response to potential treatments in clinical trials. The present review, while initially providing a comprehensive description of the pathophysiology involved in AMD, aims to offer an overview of the imaging modalities employed in the evaluation of non-neovascular AMD. Special emphasis is placed on the assessment of progression biomarkers as discerned through optical coherence tomography. As the landscape of AMD treatment continues to evolve, advanced imaging techniques will remain at the forefront, enabling clinicians to offer the most effective and tailored treatments to their patients.

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Section: Oct Evaluation Of Drusenmentioning

confidence: 99%

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers

Iliescu,

Ghita,

Ilie

et al. 2024

Diagnostics

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“…The usual outcome of the non-neovascular type is slow-but-steady progressive vision deterioration, which spans months to years. The first clinical sign might be drusen only, but certain peculiar structural characteristics of drusen are associated with rapid progression to advanced stages of AMD [ 59 ]. The definitive outcome of the non-exudative form is an irreversible distortion of RPE and GA [ 60 ].…”

Section: Reviewmentioning

confidence: 99%

Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness

Chaudhuri,

Hassan,

Bakka Vemana

et al. 2023

Cureus

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Age-related macular degeneration (AMD) is a significant cause of blindness globally. With the exponential rise in the aging population, AMD is the third leading cause of visual impairment worldwide. Neovascular AMD (nAMD; Wet AMD) and geographical atrophy (GA, late-stage dry AMD) are the advanced AMD accountable for substantial cases of visual deterioration among the elderly. Our review of the literature depicted that notable risk factors include cigarette smoking, nutritional elements, cardiovascular disorders, and genetic markers, including genes regulating complement, lipid, and angiogenic pathways. Some studies have suggested a relative decline in the proportion of AMD cases in the last two decades attributable to novel diagnostic and therapeutic modalities. Accurate diagnosis is the result of a combination of clinical examination and imaging techniques, including retinal photography, angiography, and optical coherence tomography. The incorporation of dietary antioxidant supplements, explicitly lutein, slows the progression of the disease in advanced stages. The induction of vascular endothelial growth factor (VEGF) inhibitors in the treatment of neovascular AMD, often combined with other modalities, has shown an immensely favorable prognosis. Research to integrate gene therapy and regenerative techniques using stem cells is underway to further mitigate AMD-associated morbidity. It is imperative to establish screening and therapeutic guidelines for AMD to curtail the future social and financial burden and improve the diminishing quality of life among the elderly.

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“…It has been applied in some ophthalmic diseases, such as diabetic retinopathy 9 and macular degeneration. 10 Research shows that the reduction of oxygen content in retinal tissue plays a role in the development of many retinal diseases, such as diabetic retinopathy, 11 arteriovenous occlusion, 12 age-related macular degeneration, 13 and glaucoma. 14 Some studies have shown that multispectral fundus imaging technology can be used as a noninvasive means to analyze the oxygen saturation in human retinal and choroidal vessels.…”

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confidence: 99%

The Diagnostic Value of Multispectral Fundus Imaging in Hypertensive Retinopathy

Bai,

Wei,

2024

Retina

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Purpose: To observe the diagnostic value of multispectral fundus imaging (MSI) in hypertensive retinopathy (HR). Methods: A total of 100 patients with HR were enrolled in this cross-sectional study, and all participants received fundus photography (FP) and MSI. Participants with severe HR received fundus fluorescein angiography (FFA). The diagnostic consistency between FP and MSI in the diagnosis of HR was calculated. The sensitivity of MSI in the diagnosis of severe HR was calculated by comparison with FFA. Choroidal vascular index (CVI) was calculated in HR patients using MSI at 780 nm. Results: MSI and FP were highly concordant in the diagnosis of HR with a Kappa value = 0.883. MSI had a sensitivity of 96% in diagnosing retinal hemorrhage (RH), a sensitivity of 89.47% in diagnosing retinal exudation (RE), a sensitivity of 100% in diagnosing vascular compression indentation (VCI), and a sensitivity of 96.15% in diagnosing retinal arteriosclerosis (RA). The CVI of the patients in the HR group was significantly lower than that of the control group, whereas there was no significant difference between the affected and fellow eyes. Conclusion: As a noninvasive modality of observation, MSI may be a new tool for the diagnosis and assessment of HR.

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Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders

Cited by 3 publications

References 46 publications

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers

Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness

The Diagnostic Value of Multispectral Fundus Imaging in Hypertensive Retinopathy

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