New high-resolution water vapor absorption spectra were obtained at room temperature in the 4200-6600 cm À1 spectral region by combining Fourier transform spectrometers (FTS) with single and multiple reflection cells. With absorption paths from 0.3 to 1800 m in pure and air diluted water vapor, accurate measurements of about 10400 lines in an intensity range from 10 À29 to 10 À19 cm/molecule have been performed. Positions, intensities, self-and air-broadening coefficients and air-induced shifts were determined for the H 2 16 O, H 2 17 O, H 2 18 O and HDO isotopologues. The rovibrational assignment of the observed lines was performed with the use of global variational predictions and allowed the identification of several new energy levels. One major contribution of this work consists of the identification of 3280 new weak lines. A very close agreement between the new measured parameters and those listed in the database is reported as well as between the observations and the most recent variational calculations for the positions and the intensities. The present parameters provide an extended and homogeneous data set for water vapor, which is shown to significantly improve the databases for atmospheric applications, especially in the transmission windows on both sides of the band centered at 5400 cm À1 .