This paper reports the results of an extensive study concerning surge instability in an industrial compression system and its dynamic suppression. Both numerical simulations and experiments have been used to analyse the system behaviour under unstable operating conditions and to compare different control devices for surge suppression. First, the characterization of surge is performed over the whole unstable operating range of a compression system based on a four-stage centrifugal compressor. The unsteady energy associated with the surge cycle is employed as an index of the surge intensity to allow for a quantitative approach to the problem. Subsequently, the behaviour and performance of a passive-type control system and of an active-type one are analysed and compared. The former consists of an innovative device based on an oscillating water column, whereas the latter is a high-gain type of feedback device implemented digitally. Experimental data show that the proposed passive device is effective not only in inhibiting surge development, but also in suppressing fully developed instability. The active device turns out to be more effective than the passive one, but under severe conditions it may fail because of actuator limitations and noise amplification. Finally, the relative merits and limitations of the two control systems are discussed with reference to their effectiveness range, flexibility, steady-state performance, installation, maintenance, and costs.