Multistage vector delivery of sulindac and silymarin for prevention of colon cancer

Scavo, Maria Principia; Gentile, Emanuela; Wolfram, Joy; Gu, Jianhua; Barone, M.; Evangelopoulos, Michael; Martinez, Jonathan O.; Liu, Xuewu; Celia, Christian; Tasciotti, Ennio; Vilar, Eduardo; Shen, Haifa

doi:10.1016/j.colsurfb.2015.10.005

Cited by 38 publications

(24 citation statements)

References 53 publications

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“…Depending on the application, the second stage vector can be any currently available nanoparticles, such as liposomes,[19a,24b,57,58] micelles,[25c,55,59] polyplexes, polymer nanoparticles,[24b,25d] and imaging agents. [4m,25b] At the lesion sites, nanoparticles released from the quasi‐hemispherical or discoidal PSi microparticles address the biological barriers in extracellular and intracellular compartments, delivering the third stage vector, such as chemotherapeutic agents like paclitaxel (PTX),[25c,d] doxorubicin (DOX), docetaxel,[24b] nonsteroidal anti‐inflammatory drug, and siRNAs,[19a,24b,57,58b,60] for the treatment of diseases. For example, clinically used nanoparticle albumin‐bound paclitaxel (nAb‐PTX) was loaded into discoidal PSi microparticles (diameter of 1 µm and thickness of 400 nm), which enabled the cross of the drug through the tumor vessel wall and enhanced its interaction with liver macrophages, and eventually increased the efficacy of nAb‐PTX and survival in mouse models of breast and lung liver metastasis.…”

Section: Psi With Controllable Geometrymentioning

confidence: 99%

“…[4k] When quasi‐hemispherical or discoidal PSi microparticles are applied as carriers of imaging agents only, like other types of PSi particles, their surface has the possibility to be used for the electrostatic attraction or covalent bonding of numerous kinds of dyes, fluorophores, fluorescent/radioactive molecules, and other imaging agents. [16a,25b,26b,54e,59,61] The most unique characteristic of quasi‐hemispherical and discoidal PSi microparticles is that they not only act as carriers for magnetic resonance imaging (MRI) contrast agents but also enhance the imaging capability of the MRI contrast agents. [4m,25b] MRI is one of the most powerful and noninvasive diagnostic imaging technique, and contrast agents are widely used to improve its sensitivity and specificity.…”

Section: Psi With Controllable Geometrymentioning

confidence: 99%

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Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

et al. 2018

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In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. Here, an overview of recent progress in the use of PSi in drug delivery and cancer immunotherapy is presented. First, an overview of the fabrication of PSi with various geometric structures is provided, with particular focus on how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to the strengthening of its performance in drug delivery and bioimaging. Emerging technologies for engineering PSi-based composites are then summarized. Emerging PSi advances in the context of cancer immunotherapy are also highlighted. Overall, very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.

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Section: Psi With Controllable Geometrymentioning

confidence: 99%

Section: Psi With Controllable Geometrymentioning

confidence: 99%

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

et al. 2018

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“…In addition to label indications, many studies have reported the beneficial effects of silymarin for the treatment of several diseases (Fig. ), including sepsis (Kang et al ., ; Toklu et al ., ), burns (Toklu et al ., ), osteoporosis (Kim et al, ; Mohd Fozi et al ., ), arthritis (Gupta et al ., ), hypercholesterolemia (Krecman et al, ; Skottova and Krecman, ), cancer (Singh et al, ; Bosch‐Barrera and Menendez, ; Scavo et al, ; Yurtcu et al, ), viral infections (Lani et al, ), diabetes (Malekinejad et al , ; Soto et al , ; Zhang et al , ; Ebrahimpour Koujan et al , ), Alzheimer's disease (Duan et al, ; Kumar et al, ), and Parkinson's disease (Haddadi et al, ; Lee et al, ). Silymarin treatment likewise attenuated the severity of radiotherapy‐induced mucositis in a clinical trial (Elyasi et al , ).…”

Section: Silymarinmentioning

confidence: 99%

Effects of Silymarin on Diabetes Mellitus Complications: A Review

2017

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Diabetes mellitus is a common metabolic disorder that is caused by a deficit in the production of (type 1) or response to (type 2) insulin. Diabetes mellitus is characterized by a state of chronic hyperglycemia and such symptoms as weight loss, thirst, polyuria, and blurred vision. These disturbances represent one of the major causes of morbidity and mortality nowadays, despite available treatments, such as insulin, insulin secretagogues, insulin sensitizers, and oral hypoglycemic agents. However, many efforts have been made to discover new drugs for diabetes treatment, including medicinal plant extracts. Silymarin is a powder extract of the seeds from Silybum marianum, a plant from the Asteraceae family. The major active ingredients include four isomers: silybin, isosilybin, silychristin, and silydianin. Silymarin is indicated for the treatment of hepatic disorders, such as cirrhosis, chronic hepatitis, and gallstones. Moreover, several studies of other pathologies, including diabetes, sepsis, osteoporosis, arthritis, hypercholesterolemia, cancer, viral infections, and Alzheimer's and Parkinson's diseases, have tested the effects of silymarin and reported promising results. This article reviews data from clinical, in vivo, and in vitro studies on the use of silymarin, with a focus on the complications of diabetes, including nephropathy, neuropathy, healing delays, oxidative stress, hepatotoxicity, and cardiomyopathy. Copyright © 2017 John Wiley & Sons, Ltd.

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“…This versatility, combined with the ability to control the release kinetics of a payload [ 70 ], makes MSV a promising tool for theranostics applications [ 71 , 72 ]. Furthermore, porous silicon as a material has been extensively studied for various medical applications including diagnostics, drug delivery, implantables, and tissue engineering [ 73 , 74 ].…”

Section: Multistage Nanovectorsmentioning

confidence: 99%

Trends towards Biomimicry in Theranostics

et al. 2018

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Over the years, imaging and therapeutic modalities have seen considerable progress as a result of advances in nanotechnology. Theranostics, or the marrying of diagnostics and therapy, has increasingly been employing nano-based approaches to treat cancer. While first-generation nanoparticles offered considerable promise in the imaging and treatment of cancer, toxicity and non-specific distribution hindered their true potential. More recently, multistage nanovectors have been strategically designed to shield and carry a payload to its intended site. However, detection by the immune system and sequestration by filtration organs (i.e., liver and spleen) remains a major obstacle. In an effort to circumvent these biological barriers, recent trends have taken inspiration from biology. These bioinspired approaches often involve the use of biologically-derived cellular components in the design and fabrication of biomimetic nanoparticles. In this review, we provide insight into early nanoparticles and how they have steadily evolved to include bioinspired approaches to increase their theranostic potential.

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Multistage vector delivery of sulindac and silymarin for prevention of colon cancer

Cited by 38 publications

References 53 publications

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

Effects of Silymarin on Diabetes Mellitus Complications: A Review

Trends towards Biomimicry in Theranostics

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