Multistimuli-responsive magnetic assemblies

Baykal, A.; Bozkurt, Ayhan; Jeremy, Ravindran; Asiri, Sarah Mousa; Lima-Tenório, Michele K.; Kaewsaneha, Chariya; Elaı̈ssari, Abdelhamid

doi:10.1016/b978-0-08-101995-5.00006-4

Cited by 5 publications

(3 citation statements)

References 131 publications

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“…Following the strategy of supramolecular metallodrugs, we investigate the host–guest binding between our new Pt(II) compounds and macrocyclic cavitands. Because of the most favorable fit between the adamantyl anchor (180 Å 3 ) used in our compounds and the internal cavity of β-CD (262 Å 3 ) and CB7 (279 Å 3 ), these two macrocycles were selected for further investigation. The reported host–guest complexes were prepared in situ by mixing the coordination compound with the macrocycle in H 2 O or D 2 O.…”

Section: Results and Discussionmentioning

confidence: 99%

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

et al. 2021

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Platinum-based anticancer drugs are actively developed utilizing lipophilic ligands or drug carriers for the efficient penetration of biomembranes, reduction of side effects, and tumor targeting. We report the development of a supramolecular host–guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host. The host–guest binding and hydrolysis process on the platinum core were investigated in detail by using NMR, MS, X-ray diffraction, and relativistic DFT calculations. The encapsulation process in cucurbit[7]uril unequivocally promotes the stability of hydrolyzed dicationic cis-[PtII(NH3)2(H2O)(NH2-R)]2+ compared to its trans isomer. Biological screening on the ovarian cancer lines A2780 and A2780/CP shows time-dependent toxicity. Notably, the reported complex and its β-cyclodextrin (β-CD) assembly achieve the same cellular uptake as cisplatin and cisplatin@β-CD, respectively, while maintaining a significantly lower toxicity profile.

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Section: Results and Discussionmentioning

confidence: 99%

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

et al. 2021

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“…Magnetic nanoparticles (MNPs) have attracted interest in biomedical applications, due to their targeted delivery platform and capacity for controlled therapeutic release, by applying an external magnetic field. Superparamagnetic nanoparticles are typically used as magneticresponsive gates by nanocapping (structure I) or incorporatiion with other responsive polymers, such as pH-responsive or temperature responsive polymers [124,129]. For example, pHresponsive nanocomposites of magnetic mesoporous silica were developed for hyperthermia cancer treatments [6].…”

Section: Magnetic-responsive Gatesmentioning

confidence: 99%

Smart gating porous particles as new carriers for drug delivery

Thananukul

Kaewsaneha

Opaprakasit

et al. 2021

Advanced Drug Delivery Reviews

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“…Cyclodextrins have different water solubility: α- and γ-cyclodextrins have a relatively high solubility (145 and 232 g·L −1 ), whereas the β-type is much less soluble in water (18.5 g·L −1 ). Image taken and modified from [ 88 ]. ( C ).…”

Section: Figurementioning

confidence: 99%

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

Bonilla

Pérez-Idárraga

Odriozola-Martínez

et al. 2020

IJERPH

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Post-exercise recovery is a broad term that refers to the restoration of training capacity. After training or competition, there is fatigue accumulation and a reduction in sports performance. In the hours and days following training, the body recovers and performance is expected to return to normal or improve. ScienceDirect, PubMed/MEDLINE, and Google Scholar databases were reviewed to identify studies and position declarations examining the relationship between nutrition and sports recovery. As an evidence-based framework, a 4R’s approach to optimizing post-exercise recovery was identified: (i) Rehydration—a fundamental process that will depend on the athlete, environment and sports event; (ii) Refuel—the consumption of carbohydrates is not only important to replenish the glycogen reserves but also to contribute to the energy requirements for the immune system and tissue reparation. Several bioengineered carbohydrates were discussed but further research is needed; (iii) Repair—post-exercise ingestion of high-quality protein and creatine monohydrate benefit the tissue growth and repair; and (iv) Rest—pre-sleep nutrition has a restorative effect that facilitates the recovery of the musculoskeletal, endocrine, immune, and nervous systems. Nutritional consultancy based on the 4R’s is important for the wise stewardship of the hydration, feeding, and supplementation strategies to achieve a timely recovery.

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Multistimuli-responsive magnetic assemblies

Cited by 5 publications

References 131 publications

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

Smart gating porous particles as new carriers for drug delivery

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

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