Multisystem Inflammatory Syndrome in Children Undergoing Covid-19

Dubrovina, Yu.A.; Легонькова, Т И; Vodneva, L.M.; Shtykova, O.N.; Shpakovskaya, K.S.; Melnikova, V.M.; Artyomenkova, E.I.

doi:10.37903/vsgma.2022.3.17

Вестник СГМА

2022

DOI: 10.37903/vsgma.2022.3.17

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Multisystem Inflammatory Syndrome in Children Undergoing Covid-19

Yu.A. Dubrovina

Т И Легонькова

L.M. Vodneva

et al.

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2023

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Current understanding of epidemiology and pathogenesis of multisystem inflammatory syndrome associated with SARS-CoV-2 in children

Konstantinova,

Vilnits,

Bekhtereva

et al. 2023

MES

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The review is dedicated to matters related to epidemiology and pathogenesis of multisystem inflammatory syndrome associated with SARS-CoV-2 in children (MIS-C). The majority of the reviewed reports are focused on immunopathogenesis of the disease. The causes of the syndrome related to the features of the virus are listed in the paper, the association with circulating variants is described. The role of the SARS-CoV-2 surface protein as superantigen is considered. The literature data on the likelihood of MIS-C development according to the antibody-dependent enhancement pattern are discussed. The factors of cellular and humoral immune response contributing to hyperinflammation are addressed. Sporadic papers describing genetic mutations that can play a certain role in the MIS-C pathogenesis are provided. Furthermore, the association of vaccination against novel coronavirus infection with the likelihood of MIS-C in vaccinated individuals is discussed.

show abstract

Current understanding of epidemiology and pathogenesis of multisystem inflammatory syndrome associated with SARS-CoV-2 in children

Konstantinova,

Vilnits,

Bekhtereva

et al. 2023

MES

View full text Add to dashboard Cite

show abstract

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Multisystem Inflammatory Syndrome in Children Undergoing Covid-19

Cited by 1 publication

References 0 publications

Current understanding of epidemiology and pathogenesis of multisystem inflammatory syndrome associated with SARS-CoV-2 in children

Current understanding of epidemiology and pathogenesis of multisystem inflammatory syndrome associated with SARS-CoV-2 in children

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