Multitarget FISH and LOH Analyses at Chromosome 3p in Non–Small Cell Lung Cancer and Adjacent Bronchial Epithelium

Woenckhaus, Matthias; Grepmeier, Ulrike; Wild, Peter J.; Merk, Johannes; Pfeifer, Michael; Woenckhaus, Ulrike; Stoelcker, Benjamin; Blaszyk, Hagen; Hofstaedter, Ferdinand; Dietmaier, Wolfgang; Hartmann, Arndt

doi:10.1309/c4bk7gqv8e5xu2tl

Cited by 17 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future studies that based on parallel plasma and tissue samples may provide more solid evidence. For the included profiling studies in which adjacent corresponding normal lung tissue served as an expression baseline, we need to know that adjacent appearing morphologically normal tissue may contain molecular changes associated with cancer [40,41]. …”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

Guan

Yin

et al. 2012

J Exp Clin Cancer Res

153

147

View full text Add to dashboard Cite

BackgroundLung cancer is the major cause of cancer death globally, it is often diagnosed at an advanced stage and has one of the lowest survival rates of any type of cancer. The common interest in the field of lung cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. There is increasing evidence to suggest that microRNAs play important and complex roles in lung cancer.MethodsA meta-analysis was conducted to review the published microRNA expression profiling studies that compared the microRNAs expression profiles in lung cancer tissues with those in normal lung tissues. A vote-counting strategy that considers the total number of studies reporting its differential expression, the total number of tissue samples used in the studies and the average fold change was employed.ResultsA total of 184 differentially expressed microRNAs were reported in the fourteen microRNA expression profiling studies that compared lung cancer tissues with normal tissues, with 61 microRNAs were reported in at least two studies. In the panel of consistently reported up-regulated microRNAs, miR-210 was reported in nine studies and miR-21 was reported in seven studies. In the consistently reported down-regulated microRNAs, miR-126 was reported in ten studies and miR-30a was reported in eight studies. Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis, with the other 14 microRNAs solely reported in one or the other subset.ConclusionsIn conclusion, the top two most consistently reported up-regulated microRNAs were miR-210 and miR-21. The results of this meta-analysis of human lung cancer microRNA expression profiling studies might provide some clues of the potential biomarkers in lung cancer. Further mechanistic and external validation studies are needed for their clinical significance and role in the development of lung cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

Guan

Yin

et al. 2012

J Exp Clin Cancer Res

153

147

View full text Add to dashboard Cite

show abstract

“…This is accomplished with the use of microsatellite markers targeting specific chromosomal loci near or in genes that are known or suspected to be implicated in the pathogenesis of a disease [4,7]. Loss of heterozygosity and microsatellite DNA instability are genetic alterations that have M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 been initially reported in a number of human cancers and in precancerous and malignant lesions of smokers [8][9][10][11][12][13][14][15][16][17]. However, during recent years such phenomena have also been detected in various benign pulmonary and extra-pulmonary diseases [5,7,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%